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Chemical Structure| 212332-40-6 Chemical Structure| 212332-40-6

Structure of 212332-40-6

Chemical Structure| 212332-40-6

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Product Details of [ 212332-40-6 ]

CAS No. :212332-40-6
Formula : C8H10BrNO
M.W : 216.08
SMILES Code : CC(OC1=CN=CC(Br)=C1)C
MDL No. :MFCD14702748
InChI Key :ASEHPOZWQJRWAD-UHFFFAOYSA-N
Pubchem ID :10584808

Safety of [ 212332-40-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H302-H311+H331-H315-H319-H335
Precautionary Statements:P261-P280-P305+P351+P338-P311
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 212332-40-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 212332-40-6 ]

[ 212332-40-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 73183-34-3 ]
  • [ 212332-40-6 ]
  • [ 1171892-42-4 ]
YieldReaction ConditionsOperation in experiment
With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In acetonitrile; at 160℃; for 0.25h;Inert atmosphere; Biotage "Initiator" microwave; Intermediate 70:3-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineA mixture of 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi-1,3,2-dioxaborolane (705mg, 2.78mmol), 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride dichloromethane complex (76mg, 0.093mmol), potassium acetate (681 mg, 6.94mmol) was sealed in a microwave vial and placed under nitrogen via a needle through the septum and applying alternately vacuum and nitrogen. A solution of 3-bromo-5-[(1-methylethyl)oxy]pyridine (500mg, 2.314mmol) in anhydrous acetonitrile (1OmL) was added, the solution degassed by alternate application of vacuum and nitrogen. The reaction mixture was then heated in a Biotage "Initiator" microwave at 16O0C for 15 minutes. After cooling, the reaction was filtered and the filtrate evaporated to dryness to give the crude (approximately 60% pure by NMR analysis) title compound (960mg, >; 100% yield) which was used subsequently without further purification. LCMS (Method A): Rt 0.65 minutes; m/z 182 (ionizes as the boronic acid).
 

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