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Chemical Structure| 210539-04-1

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6-Benzyl-2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine

CAS No.: 210539-04-1

4.5 *For Research Use Only !

Cat. No.: A265491 Purity: 98%

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Product Details of [ 210539-04-1 ]

CAS No. :210539-04-1
Formula : C15H15ClN2
M.W : 258.75
SMILES Code : ClC1=NC2=C(CN(CC3=CC=CC=C3)CC2)C=C1
MDL No. :MFCD09040695
InChI Key :BPAUBEUYIXYWAV-UHFFFAOYSA-N
Pubchem ID :16228747

Safety of [ 210539-04-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 210539-04-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210539-04-1 ]

[ 210539-04-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 210539-04-1 ]
  • [ 24424-99-5 ]
  • [ 1151665-15-4 ]
YieldReaction ConditionsOperation in experiment
75% Example 26 2-(3-Furyl)-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride (step 1) To a solution of the compound (2.00 g) obtained in Example 6, step 2 in dichloroethane (30 mL) was added 1-chloroethyl chloroformate (0.917 mL), and the mixture was stirred at 90C for 2 hr. The reaction mixture was cooled to room temperature, and concentrated. To the obtained residue was added methanol (20 mL), and the mixture was stirred under reflux for 1 hr. To the reaction mixture was added diisopropyl ether (30 mL), and the precipitate was collected by filtration. A mixed solution of the obtained solid (1.55 g) and (Boc)2O (1.69 g) in THF/1N aqueous sodium hydroxide solution (23 mL/23 mL) was stirred at room temperature for 16 hr. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to give tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (1.56 g, 75%) as a white powder. 1H-NMR(CDCl3):delta1.49(9H,s), 2.97(2H,t,J=6.0Hz), 3.73(2H,d,J=6.0Hz), 4.56(2H,s), 7.17(1H,d,J=8.2Hz), 7.38(1H,d,J=8.2Hz)
 

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