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Chemical Structure| 210354-17-9 Chemical Structure| 210354-17-9

Structure of 210354-17-9

Chemical Structure| 210354-17-9

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Product Details of [ 210354-17-9 ]

CAS No. :210354-17-9
Formula : C10H7BrN2
M.W : 235.08
SMILES Code : BrC1=CC=C(C2=NC=CC=N2)C=C1
MDL No. :MFCD08056329

Safety of [ 210354-17-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313

Application In Synthesis of [ 210354-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210354-17-9 ]

[ 210354-17-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7560-83-0 ]
  • [ 623-70-1 ]
  • [ 131274-22-1 ]
  • [ 210354-17-9 ]
  • [ 545426-62-8 ]
YieldReaction ConditionsOperation in experiment
0.47 g (70%) tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; Step A (2E)-3-[4-(2-Pyrimidinyl)phenyl]-2-butenoic Acid Ethyl Ester Dioxane (2 mL) was added to a mixture of 2-(4-bromophenyl)pyrimidine (0.59 g, 2.51 mmol, prepared as described in U.S. Pat. No. 5,780,473), tri-t-butylphosphonium tetrafluoroborate (36 mg, 0.12 mmol), and tris(dibenzylideneacetone)dipalladium(0) (57 mg, 0.062 mmol). N-Methyldicyclohexylamine (0.64 mL, 2.99 mmol) and ethyl crotonate (0.62 mL, 4.99 mmol) were added and the mixture was stirred for 18 h at room temperature. The mixture was diluted with ethyl acetate, filtered through a small plug of silica gel which was washed with additional ethyl acetate, and the combined filtrates were concentrated. Purification by chromatography (SiO2, 5:1 hexane/ethyl acetate) provided 0.47 g (70percent) of the title compound as an off-white solid. MS 269 (M+H)+.
 

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