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Chemical Structure| 209968-27-4 Chemical Structure| 209968-27-4

Structure of 209968-27-4

Chemical Structure| 209968-27-4

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Product Details of [ 209968-27-4 ]

CAS No. :209968-27-4
Formula : C12H17BrN2O2S
M.W : 333.25
SMILES Code : O=S(C1=CC=C(Br)C=C1)(NCCN2CCCC2)=O
MDL No. :MFCD02556611

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Application In Synthesis of [ 209968-27-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 209968-27-4 ]

[ 209968-27-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 209968-27-4 ]
  • [ 936845-78-2 ]
YieldReaction ConditionsOperation in experiment
41% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane;Heating / reflux; To a solution of 4-bromo-N-(2-pyrrolidin-l-yl-ethyl)-benzenesulfonamide (1.33 g, 4.0 mmol) in 1,4-dioxane (200 mL) was added <strong>[1003-61-8]2-aminothiazole-5-carbaldehyde</strong> (0.51 g, 4.0 mmol), Cs2CO3 (5.2 g, 16.0 mmol), Pd2(dba)3 (0.37 g, 0.4 mmol), and 4,5- bis(diphenylphosphino)-9,9-dimethyxanthene (Xant Phos, 0.69 g, 1.6 mmol). The mixture was heated under reflux overnight under Ar. The solid was filtered off and the filtrate washed with brine (I x 200 mL). The organic solution was separated and dried (Na2SO4). The solution was concentrated until 5 mL remaining and hexanes (50 mL) added, the solid was collected by filtration to afford the title intermediate (0.62 g, 41%) as a yellow solid.
 

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