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Chemical Structure| 206055-86-9 Chemical Structure| 206055-86-9
Chemical Structure| 206055-86-9

[3-(4-Methoxyphenyl)isoxazol-5-yl]methanol

CAS No.: 206055-86-9

4.5 *For Research Use Only !

Cat. No.: A114296 Purity: 95%

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Product Details of [ 206055-86-9 ]

CAS No. :206055-86-9
Formula : C11H11NO3
M.W : 205.21
SMILES Code : COC1=CC=C(C=C1)C2=NOC(=C2)CO
MDL No. :MFCD04124287
InChI Key :SROFDUACOHNMJB-UHFFFAOYSA-N
Pubchem ID :1471841

Safety of [ 206055-86-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 206055-86-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 206055-86-9 ]

[ 206055-86-9 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 206055-86-9 ]
  • [ 325744-41-0 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In dichloromethane; at 20.0℃;Inert atmosphere; General procedure: To a stirred solution of ?a? derivatives in freshly distilled CH2Cl2 under N2 atmosphere, at roomtemperature, thionyl chloride (1.5 eq) was added. The reactions were monitored by TLC and, at thetotal consumption of the starting material, they were quenched with cold water and extracted withCH2Cl2. Next, the crude products were solubilized in DMF followed by addition of sodium azide (1.5eq). The reactions were kept at room temperature until TLC analyses indicated the disappearance ofthe starting material, then, they were quenched with water and extracted with EtOAc. In the last step,the crude azide derivatives were solubilized in THF followed by addition of triphenylphosphine (1.5 eq).The reactions were maintained overnight at room temperature, quenched by addition of aqueousNa2CO3 [5% (m/v)] and extracted with EtOAc. The crude amine derivatives (compound d) were usedfor the synthesis of the isoxazolyl-sulfonamide derivatives 1-20 without any further purification.
 

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