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Chemical Structure| 205240-59-1 Chemical Structure| 205240-59-1

Structure of 205240-59-1

Chemical Structure| 205240-59-1

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Product Details of [ 205240-59-1 ]

CAS No. :205240-59-1
Formula : C6H2ClF3IN
M.W : 307.44
SMILES Code : FC(C1=CC=C(I)C(Cl)=N1)(F)F
MDL No. :MFCD15478058

Safety of [ 205240-59-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 205240-59-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 205240-59-1 ]

[ 205240-59-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 205240-59-1 ]
  • [ 205444-22-0 ]
YieldReaction ConditionsOperation in experiment
81% With lithium diisopropyl amide; In tetrahydrofuran; at -78℃; for 1h;Inert atmosphere; To a mixture of 2-chloro-3-iodo-6-(trifluoromethyl)pyridine (3.07 g, 10.0 mmol) in THF (35 mL) was added dropwise LDA (5.5 mL, 2M) at -78 oC via syringe under N2 atmosphere. The reaction mixture was stirred at that temperature for 1 h. The reaction mixture was quenched with aqueous HCl (15mL, 1 M) at -78 oC and stirred for 0.5 h. The mixture was warmed to r.t., stirred for another 0.5 hr, and then concentrated under reduced pressure. The aqueous layer was separated and extracted with EA (2 x 100 mL). Combined organic layers were washed with water and brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue was purified by column chromatography (eluted with PE) to give the 2-chloro-4-iodo-6- (trifluoromethyl)pyridine (2.5 g, 81% yield) as a white solid. 1HNMR (400 MHz, DMSO-d6) delta 8.39 (s, 1H), 8.34 (s, 1H).
 

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