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Chemical Structure| 204394-69-4 Chemical Structure| 204394-69-4

Structure of 204394-69-4

Chemical Structure| 204394-69-4

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Product Details of [ 204394-69-4 ]

CAS No. :204394-69-4
Formula : C10H5ClF3N3
M.W : 259.62
SMILES Code : FC(C1=CC(Cl)=NC(C2=CC=CN=C2)=N1)(F)F
MDL No. :MFCD00140057

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Application In Synthesis of [ 204394-69-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 204394-69-4 ]

[ 204394-69-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 204394-69-4 ]
  • [ 2305-79-5 ]
  • 4-(4,5,6,7-Tetrahydro-1H-indazolyl)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 171 4-(4,5,6,7-Tetrahydro-1H-indazolyl)-2-(3-pyridinyl)-6-trifluoromethylpyrimidine The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (76 mg, 0.293 mmol) and <strong>[2305-79-5]4,5,6,7-tetrahydroindazole</strong> (44 mg, 0.360 mmol) similar to Example 166 and was isolated as a white solid (25 mg, 0.072 mmol, 25% %). 1H NMR (CDCl3) 9.68 (d, J 1.2 Hz, 1H), 8.75 (m, 2H), 8.40 (s, 1H), 8.07 (s, 1H), 7.45 (ddd, J=1.2, 5.1, 9.0 Hz, 1H), 2.73 (m, 4H), 1.88 (m, 4H).
  • 2
  • [ 204394-69-4 ]
  • [ 6358-77-6 ]
  • [ 438248-62-5 ]
YieldReaction ConditionsOperation in experiment
32% b. 4-(5-Bromo-2-methoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and <strong>[6358-77-6]5-bromo-2-methoxyaniline</strong> (39 mg, 0.193 mmol) similar to Example 117 and isolated as a tan solid (26 mg, 32%). 1H NMR (CDCl3): 9.67-9.66 (m, 1H), 8.77-8.71 (m, 3H), 7.55 (s, 1H), 7.48-7.43 (m, 1H), 7.24 (dd, J=2.4, 8.7 Hz, 1H), 6.92 (s, 1H), 6.83 (d, J=9.0 Hz, 1H), 3.93 (s, 3H).
 

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