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Chemical Structure| 203520-35-8 Chemical Structure| 203520-35-8

Structure of 203520-35-8

Chemical Structure| 203520-35-8

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Product Details of [ 203520-35-8 ]

CAS No. :203520-35-8
Formula : C14H26N4O3
M.W : 298.39
SMILES Code : O=C(N1CCN(C(N2CCNCC2)=O)CC1)OC(C)(C)C
MDL No. :MFCD24469802

Safety of [ 203520-35-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 203520-35-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 203520-35-8 ]

[ 203520-35-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 203520-35-8 ]
  • [ 22282-75-3 ]
  • [ 6163-58-2 ]
  • [ 211820-06-3 ]
YieldReaction ConditionsOperation in experiment
tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; methanol; dichloromethane; Tris(dibenzylideneacetone)dipalladium(0) (0.184 g) and tri-o-tolylphosphine (0.244 g) were added to a suspension of <strong>[22282-75-3]3-fluoro-4-iodopyridine</strong> (4.46 g), 1-[1-(t-butoxycarbonyl)piperazin-4-ylcarbonyl]piperazine (3.0 g) and sodium t-butoxide (2.12 g) in dry 1,4-dioxane (40 ml) under an atmosphere of argon. The mixture was heated at 100° C. for 18 hours. The mixture was cooled, diluted with diethyl ether (200 ml) and washed with saturated brine (40 ml). The aqueous layer was back-extracted with diethyl ether (2*100 ml). The ether layers were all combined, washed with saturated brine (2*100 ml), dried (Na2SO4) and evaporated. The residual oil was purified by chromatography on alumina (N32-63) using 0.1-0.4percent methanol in dichloromethane as eluent to give 1-(t-butoxycarbonyl)-4-[1-(3-fluoro-4-pyridyl)piperazin-4-ylcarbonyl]piperazine (1.7 g) as an orange solid: NMR (CDCl3): 1.47 (s, 9H), 3.25 (m, 8H), 3.45 (m, 8H), 6.75 (dd, 1H), 8.20 (dd, 2H); m/z 394 (M+1).
 

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