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Chemical Structure| 203519-88-4 Chemical Structure| 203519-88-4

Structure of 203519-88-4

Chemical Structure| 203519-88-4

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Product Details of [ 203519-88-4 ]

CAS No. :203519-88-4
Formula : C13H19ClN4O2
M.W : 298.77
SMILES Code : CC(C)(C)OC(=O)N1CCN(CC1)C1=CC(Cl)=NC=N1
MDL No. :MFCD09607868
InChI Key :OKGUCUQGOHTRAC-UHFFFAOYSA-N
Pubchem ID :18697980

Safety of [ 203519-88-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 203519-88-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 203519-88-4 ]

[ 203519-88-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 203519-88-4 ]
  • [ 936845-92-0 ]
YieldReaction ConditionsOperation in experiment
70% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160℃; for 0.25h;Irradiation; In a dry 15mL microwave vial were combined intermediate 31 (1.1 g, 3.7 mmol), 2-amino-thiazole-5-carbaldehyde (0.56 g, 4.4 mmol), cesium carbonate (3.6 g, 11 mmol), Xantphos (0.42 g, 0.73 mmol) and tris(dibenzylideneacetone) dipalladium (0.34 g, 0.37 mmol). Reactants were diluted with dioxane (12 mL), flushed with argon and irradiated for 15 min at 160 0C. Reaction was then diluted with EtOAc and filtered. Solvents were then removed and resulting residue purified via column chromatography (silica gel) to provide title intermediate as brown powder (I g, 70%).
 

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