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Chemical Structure| 203519-37-3 Chemical Structure| 203519-37-3
Chemical Structure| 203519-37-3

tert-Butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

CAS No.: 203519-37-3

4.5 *For Research Use Only !

Cat. No.: A368374 Purity: 95%

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Product Details of [ 203519-37-3 ]

CAS No. :203519-37-3
Formula : C14H21ClN4O2
M.W : 312.80
SMILES Code : CC1=NC(=CC(Cl)=N1)N1CCN(CC1)C(=O)OC(C)(C)C
MDL No. :MFCD09972246

Safety of [ 203519-37-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 203519-37-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 203519-37-3 ]

[ 203519-37-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 203519-37-3 ]
  • [ 936845-85-1 ]
YieldReaction ConditionsOperation in experiment
42% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; for 7h;Heating / reflux; In a dry 100 mL round bottom flask were combined intermediate 19 (2.8 g, 8.9 mmol), 2-amino-thiazole-5-carbaldehyde (1.4 g, 10.7 mmol), cesium carbonate (8.7 g, 26.7 mmol), Xantphos (1.03 g, 1.8 mmol) and tris(dibenzylideneacetone) dipalladium (0.82 g, 0.89 mmol). Reactants were diluted with dioxane (40 mL), flushed with argon and refluxed for 7 h. Reaction was then diluted with EtOAc and filtered. Solvents were then removed and resulting residue purified via column chromatography (silica gel) to provide title intermediate as yellow powder (1.5 g, 42%).[0130] 1H NMR (500 MHz, DMSO-d6): d 1.42 (s, 9H), 2.42 (s, 3H), 3.42 (m, 4H), 3.54 (m, 4H), 6.10 (s, IH), 8.30 (s, IH), 9.85 (s, IH), 11.90 (s, IH). MS (ES+): m/z 405 (M+H)+.
 

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