Home Cart Sign in  
Chemical Structure| 2033-46-7 Chemical Structure| 2033-46-7

Structure of 2033-46-7

Chemical Structure| 2033-46-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 2033-46-7 ]

CAS No. :2033-46-7
Formula : C6H7IN2OS
M.W : 282.10
SMILES Code : CC(NC1=NC(C)=C(I)S1)=O
MDL No. :MFCD09863881

Safety of [ 2033-46-7 ]

Application In Synthesis of [ 2033-46-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2033-46-7 ]

[ 2033-46-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2033-46-7 ]
  • [ 214360-70-0 ]
  • [ 916138-11-9 ]
YieldReaction ConditionsOperation in experiment
66% With potassium fluoride;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; toluene; at 120℃; for 0.25h; In a microwave tube, N-(5-iodo-4-methyl-l,3-thiazol-2-yl)acetamide, Intermediate 1 (564.2 mg; 2 mmol; 1 eq) and Pd(dppi)Cl2 (73.2 mg; 0.10 mmol; 0.05 eq) are suspended in Toluene (7ml). A solution of potassium fluoride (464.8 mg; 8 mmol; 4 eq) in MeOH (7ml) is added. 3- (4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)thiophene (630.3 mg; 3 mmol; 1.50 eq) is finally added as a solid. The resulting solution is flushed with argon, the tube is closed and heated under microwave action at 1200C for 15 minutes. The reaction mixture is filtered over Celite and the solvents are evaporated. The resulting crude product is dissolved in EtOAc, washed with water and brine and dried over MgSO4. It is then purified by preparative HPLC, affording the title compound as white-off solid (316.7 mg; 66% yield). 1H NMR (DMSO-d6, 300 MHz) ? 2.12 (s, 3H), 2.35 (s, 3H), 7.28 (dd, J = 1.5, 4.9 Hz, IH), 7.58 (dd, J = 1.5, 3.0 Hz, IH), 7.67 (dd, J = 3.0, 4.9 Hz, IH), 12.09 (s, IH). M (ESI): 237.03; M+(ESI): 239.03. HPLC (method A), Rt: 2.92 min (purity: 99.6%).
 

Historical Records

Technical Information

Categories