Home Cart Sign in  
Chemical Structure| 2002-03-1 Chemical Structure| 2002-03-1
Chemical Structure| 2002-03-1

5-Phenyl-1,3,4-thiadiazol-2-amine

CAS No.: 2002-03-1

4.5 *For Research Use Only !

Cat. No.: A484195 Purity: 97%

Change View

Size Price

US Stock

Global Stock

In Stock
1g łË˶ÊÊ Inquiry Inquiry
5g łÿò¶ÊÊ Inquiry Inquiry
10g łîÿ¶ÊÊ Inquiry Inquiry
25g łÇóî¶ÊÊ Inquiry Inquiry

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1g

    łË˶ÊÊ

  • 5g

    łÿò¶ÊÊ

  • 10g

    łîÿ¶ÊÊ

  • 25g

    łÇóî¶ÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support Online Technical Q&A
Product Citations

Alternative Products

Product Details of [ 2002-03-1 ]

CAS No. :2002-03-1
Formula : C8H7N3S
M.W : 177.23
SMILES Code : NC1=NN=C(C2=CC=CC=C2)S1
MDL No. :MFCD00205278
InChI Key :UHZHEOAEJRHUBW-UHFFFAOYSA-N
Pubchem ID :219408

Safety of [ 2002-03-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 2002-03-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2002-03-1 ]

[ 2002-03-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2002-03-1 ]
  • [ 14437-03-7 ]
  • [ 13281-72-6 ]
  • 2
  • [ 2002-03-1 ]
  • [ 2840-29-1 ]
  • 3-amino-4-bromo-N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
13.7 g With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; To a solution of <strong>[2840-29-1]3-amino-4-bromobenzoic acid</strong> (10.0 g, 46.3 mmol) and 5-phenyl-l,3,4-thiadiazol-2- amine (6.84 g, 38.6 mmol) in DMF (140 mL) was added (benzotriazol-1- yloxy)tripyrrolidinophosphonium hexafluorophosphate (PYBOP, 40.1 g, 77.2 mmol) and diisopropylethylamine (26.9 mL, 154 mmol). The resulting mixture was stirred at room temperature over night. (Benzotriazol-l-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PYBOP, 40.1 g, 77.2 mmol) and diisopropylethylamine (26.9 mL, 154 mmol) were added and the resulting mixture was stirred at room temperature for 3 days. The mixture was concentrated under reduced pressure, was then triturated with dichloromethane, and was concentrated under reduced pressure. The remaining solids were then triturated with ethanol (300 mL) and water (300 mL), and the resulting mixture was stirred for 30 minutes. The remaining solids were removed by filtration, washed with ethanol, and were dried at 50 C under reduced pressure. The remaining solids were then triturated with ethanol (500 mL), and the resulting mixture was stirred under reflux. After cooling to room temperature, the remaining solids were removed by filtration, washed with ethanol, and were dried at 50 C under reduced pressure. The remaining solids were then triturated with toluene (300 mL), and the resulting mixture was stirred under reflux. After cooling to room temperature, the remaining solids were removed by filtration, washed with toluene, and were dried at 50 C under reduced pressure to give the title compound (13.7 g). 1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 5.64 (s, 2H), 7.25 (dd, 1H), 7.47 (d, 1H), 7.50 - 7.58 (m, 4H), 7.94 - 8.01 (m, 2H), 13.05 (s, 1H). LC-MS (Method 4): Rt = 1.18 min; MS (ESIpos): m/z = 375 [M+H]+.
 

Historical Records

Technical Information

Categories