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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 40381-90-6 Chemical Structure| 40381-90-6
Chemical Structure| 40381-90-6

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Synonyms: 2,6-Dichloropyridine-3-carbonitrile

4.5 *For Research Use Only !

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Product Details of 2,6-Dichloro-3-cyanopyridine

CAS No. :40381-90-6
Formula : C6H2Cl2N2
M.W : 173.00
SMILES Code : ClC1=NC(=CC=C1C#N)Cl
Synonyms :
2,6-Dichloropyridine-3-carbonitrile
MDL No. :MFCD03411341
InChI Key :LFCADBSUDWERJT-UHFFFAOYSA-N
Pubchem ID :12605538

Safety of 2,6-Dichloro-3-cyanopyridine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H311+H331-H315-H318
Precautionary Statements:P501-P261-P270-P271-P264-P280-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P305+P351+P338+P310-P403+P233-P405
Class:6.1
UN#:3439
Packing Group:

Application In Synthesis of 2,6-Dichloro-3-cyanopyridine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40381-90-6 ]

[ 40381-90-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 35441-10-2 ]
  • [ 40381-90-6 ]
  • 2
  • [ 40381-90-6 ]
  • [ 365564-07-4 ]
  • 2-chloro-6-(3,5-dimethoxyphenyl)nicotinonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
79.2% With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In water; isopropyl alcohol; at 90℃; for 3h;Inert atmosphere; A mixture of 1.384 g of 2,6-dichloro-nicotine and 2.325 g of 2- (3,5-dimethoxyphenyl) -4,4,5,5-tetramethyl-1,3,2-dioxaBorane was dissolved in 67.2 ml of isopropanol and 22.4 ml of an aqueous solution of sodium bicarbonate (1 mole per liter) and 0.925 g of tetrakis(Triphenylphosphine) palladium, and the temperature was raised to 90 C under argon atmosphere. After stirring for 3 hours, the reaction was stopped and the reaction mixture was separated with acetic acidEthyl ester, the organic phase was combined and washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated.The residue was chromatographed (petroleum ether: ethyl acetate = 98: 2-96: 4, V / V) to give 1.740 g of a yellow solid in 79.2% yield.
 

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