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Chemical Structure| 165047-24-5 Chemical Structure| 165047-24-5
Chemical Structure| 165047-24-5

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Product Details of 2,4,5-Trifluorobenzaldehyde

CAS No. :165047-24-5
Formula : C7H3F3O
M.W : 160.09
SMILES Code : O=CC1=CC(F)=C(F)C=C1F
MDL No. :MFCD00061196
InChI Key :CYIFJRXFYSUBFW-UHFFFAOYSA-N
Pubchem ID :519278

Safety of 2,4,5-Trifluorobenzaldehyde

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
Class:3
UN#:1989
Packing Group:

Application In Synthesis of 2,4,5-Trifluorobenzaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 165047-24-5 ]

[ 165047-24-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 349-58-6 ]
  • [ 165047-24-5 ]
  • 4-[3,5-bis(trifluoromethyl)phenoxy]-2,5-difluorobenzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With caesium carbonate; In N,N-dimethyl-formamide; at 25℃; for 2h; 3,5-bis(trifluoromethyl)phenol (2.5 g, 10.86 mmol, 1 .10 equiv) and Cs2C03 (6.5 g, 19.95 mmol, (0476) 2.00 equiv) were dissolved in DMF (30 g, 410.45 mmol, 41 .07 equiv) and 2,4,5-trifluorobenzaldehyde (1 .6 g, 9.99 mmol, 1 .00 equiv) was added. The resulting reaction was stirred for 2 h at 25°C. Then the reaction was quenched by the addition of water, extracted with ethyl acetate, and the organic layers were combined. The resulting mixture was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by silica gel column chromatography with petroleum ether. This resulted in 2 g (54percent) of 4-[3,5-bis(trifluoromethyl)phenoxy]-2,5-difluorobenzaldehyde as a white solid.
  • 2
  • [ 1025718-84-6 ]
  • [ 165047-24-5 ]
  • 4-[3-bromo-5-(trifluoromethyl)phenoxy]-2,5-difluorobenzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 1.0h; Into a 25-m L round-bottom flask was placed a solution of 2,4,5-trifluorobenzaldehyde (500 mg, 3.12 mmol, 1 .00 equiv) in N,N-dimethylformamide (10 mL). To the solution were added potassium carbonate (862 mg, 6.24 mmol, 2.00 equiv) and <strong>[1025718-84-6]3-bromo-5-(trifluoromethyl)phenol</strong> (753 mg, 3.12 mmol, 1 .00 equiv). The solution was stirred for 1 hour at room temperature and then quenched by the addition of 10 mL of water. The resulting solution was extracted with 50 m L of ethyl acetate and the combined organic layers were washed with brine (4 x 20 m L), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 1 .1 g (92%) of 4-[3-bromo-5-(trifluoromethyl)phenoxy]-2,5- difluorobenzaldehyde as a yellow solid
 

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• Alkyl Halide Occurrence • Arndt-Eistert Homologation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Knoevenagel Condensation • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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