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Chemical Structure| 1992-90-1 Chemical Structure| 1992-90-1

Structure of 1992-90-1

Chemical Structure| 1992-90-1

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Product Details of [ 1992-90-1 ]

CAS No. :1992-90-1
Formula : C6H7FN2O2S
M.W : 190.20
SMILES Code : O=S(C1=CC(F)=CC=C1N)(N)=O
MDL No. :MFCD08741368
Boiling Point : No data available

Safety of [ 1992-90-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1992-90-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1992-90-1 ]

[ 1992-90-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 620611-27-0 ]
  • [ 1992-90-1 ]
  • [ 620611-46-3 ]
YieldReaction ConditionsOperation in experiment
69% [Reference Example 36] Synthesis of 4-fluoro-4-[(7-fluoro-1,1-dioxo-4H-benzo[e]1,2,4-thiadiazine-3-yl)amino]methyl}piperidinecarboxylic acid tert-butyl ester The 4-(aminomethyl)-4-fluoropiperidinecarboxylic acidtert-butyl ester (1.0 g, 4.30 mmol) synthesised in Reference Example 3 was dissolved in acetonitrile (30.0 mL), and the solution was cooled to 0C. A solution of 1,1'-thiocarbonyldiimidazole (844 mg, 4.73 mmol) and imidazole (88 mg, 1.30 mmol) in acetonitrile (10 mL) was added dropwise thereto, and the mixture was stirred at room temperature for 2 hours. Next, 2-amino-5-fluorobenzenesulfonamide (981 mg, 5.16 mmol) and dimethylaminopyridine (630 mg, 5.16 mmol) were added to the reaction mixture which was then stirred at 80C overnight. Diisopropylcarbodiimide (0.662 mL, 4.30 mmol) was added thereto, and the mixture was stirred for 1 hour. The reaction mixture was cooled to room temperature and then concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (50 mL). This was washed with water (20 mL) and saturated brine (20 mL), and then dried over anhydrous sodium sulfate. The residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (n-hexane:ethyl acetate = 3:2 ? 2:3) to obtain 4-fluoro-4-[(7-fluoro-1,1-dioxo-4H-benzo[e]1,2,4-thiadiazine-3-yl)amino]methyl}piperidinecarboxylic acid tert-butyl ester. Yield: 1.27 g (69%), M-Boc+2H = 331.1.
 

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