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Chemical Structure| 19819-15-9 Chemical Structure| 19819-15-9

Structure of 19819-15-9

Chemical Structure| 19819-15-9

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Product Details of [ 19819-15-9 ]

CAS No. :19819-15-9
Formula : C11H12N2OS
M.W : 220.29
SMILES Code : O=C1C(C2=C(CCCC2)S3)=C3N=C(C)N1
MDL No. :MFCD00454938

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Application In Synthesis of [ 19819-15-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 19819-15-9 ]
  • Downstream synthetic route of [ 19819-15-9 ]

[ 19819-15-9 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 19819-15-9 ]
  • [ 81765-97-1 ]
YieldReaction ConditionsOperation in experiment
71% Reflux General procedure: The different thieno[2,3-d]pyrimidin-4-one (6a-d or f-i) (1 eq.) and phosphoryl chloride (2.9 mL/mmoleq.) were refluxed for 8 h. The reaction mixture was then cooled in an ice-bath and carefully neutralised by the addition of aqueous saturated NaHCO3 solution. The resulting mixture was extracted with ethylacetate (15 mL/mmol eq.), the organic layer was separated, dried over MgSO4 and concentrated. The crude residue was purified by flash column chromatography eluting with n-hexane-EtOAc 100:0 v/vincreasing to n-hexane-EtOAc 85:15 v/v unless otherwise stated.
References: [1] Chemical & Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 326 - 332.
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 31 - 47.
[3] Synthesis, 2001, # 14, p. 2119 - 2123.
  • 2
  • [ 19819-15-9 ]
  • [ 81765-97-1 ]
References: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982, vol. <B> 21, # 7, p. 666 - 668.
[2] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 5, p. 776 - 779.
 

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