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Chemical Structure| 195372-65-7 Chemical Structure| 195372-65-7

Structure of 195372-65-7

Chemical Structure| 195372-65-7

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Product Details of [ 195372-65-7 ]

CAS No. :195372-65-7
Formula : C11H13BrClNO
M.W : 290.58
SMILES Code : CC(C)(C)C(NC1=CC=C(Cl)C=C1Br)=O

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Application In Synthesis of [ 195372-65-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 195372-65-7 ]

[ 195372-65-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 383-63-1 ]
  • [ 195372-65-7 ]
  • [ 173676-59-0 ]
YieldReaction ConditionsOperation in experiment
70% Step 2: Synthesis of l-(2-amino-5-chlorophenyl)-2,2,2,-trifluoroethanone hydrochloride from 4-chloro-2-bromo phenyl pivalamide. (0120) To the mixture of Magnesium turnings (leq) and 2 vol of THF were added few particles of iodine for initiating and starting material i.e (4-chloro-2-bromophenyl)pivalamide (1 gr) at room temperature and waited for initiation. Slowly add starting material (dissolved in Ivol of THF) drop wise once initiation was started. Lithium chloride (0.25 mmol) was added to the reaction mixture after completion of addition and stirred for about 6hrs at room temperature. Cooled the reaction mixture to -15C and ethyl trifluoroacetate (1.4mmol) was added. Raised the temperature of the reaction mixture to 20C, maintained for about 30 mints and quenched the reaction mixture with ammonium chloride solution. Extracted the reaction mixture with MTBE and combined organic layers were concentrated under reduced pressure. To the crude compound thus obtained was added acetic acid (4 vol) and HC1 (2 vol). Slowly heated the reaction mixture to 75C and maintained the reaction mixture at the same temperature for about 4hrs. Cooled the reaction mixture to 0-5C for 2hrs, filtered and washed with Ivol of ethylacetate to afford 70% of title compound.
  • 2
  • [ 65854-91-3 ]
  • [ 195372-65-7 ]
YieldReaction ConditionsOperation in experiment
90% With bromine; acetic acid; at 20℃; for 1h; Step 2: Synthesis of N-(2-bromo-4-chlorophenyl)pivalamide from N-(4- chlorophenyl)pivalamide: (0083) Bromine (1.2 mmol) was added dropwise to a solution of <strong>[65854-91-3]N-(4-chlorophenyl)pivalamide</strong> (1 mmol) in acetic acid (2 vol.) at room temperature. The reaction was stirred at the same temperature for lh. After completion of the reaction the reaction mixture was poured into crushed ice to get precipitate. The precipitate was filtered and washed with water to yield 90% N-(2-bromo-4-chlorophenyl)pivalamide.
 

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