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Chemical Structure| 19411-56-4 Chemical Structure| 19411-56-4

Structure of 19411-56-4

Chemical Structure| 19411-56-4

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Product Details of [ 19411-56-4 ]

CAS No. :19411-56-4
Formula : C11H7ClO2
M.W : 206.63
SMILES Code : O=C(C1=C(Cl)C=C2C=CC=CC2=C1)O
MDL No. :MFCD02071785
InChI Key :HYHOZDGUNZYCHZ-UHFFFAOYSA-N
Pubchem ID :13463000

Safety of [ 19411-56-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 19411-56-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19411-56-4 ]

[ 19411-56-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 13220-33-2 ]
  • [ 19411-56-4 ]
  • Sodium; 3-(1-methyl-pyrrolidin-3-yloxy)-naphthalene-2-carboxylate [ No CAS ]
  • 2
  • [ 19411-56-4 ]
  • [ 67630-01-7 ]
  • [ 916834-70-3 ]
YieldReaction ConditionsOperation in experiment
57% With 2-methoxy-ethanol; copper; potassium carbonate;copper(I) oxide; at 120℃; for 1.5h;Inert atmosphere;Product distribution / selectivity; 4) Ullmann coupling between Boc-aminoPhe-OEt and 3-chloro-naphthalene-2-carboxylic acid According to Table 1, reagents except for 2-methoxyethanol were mixed. Flask was subjected to degassing by nitrogen, added with 2-methoxyethanol, and heated to 120 C. under reflux. One and a half hours later, the reaction was terminated when the spot which corresponds to CNCA was disappeared on TLC developed by a mix solvent (ethyl acetate and hexane (2:1)). The reaction solution was filtered through cotton and sellite to remove Cu. The obtained filtrate was dropped into 15 ml of distilled water. The suspension that observed precipitate, was centrifuged at 3000 rpm for 5 minutes to collect the precipitate. This precipitate was dissolved in ethyl acetate, and washed two times with respectively 5% KHSO4, 4% NaHCO3 and saturated NaCl. After dehydration using MgSO4, column purification was conducted. The column purification was conducted using developing solvents in the following order: chloroform and methanol (8:2)?chloroform and ethyl acetate (9:1)?chloroform and methanol (95:5). The obtained purified product was analyzed by 1H-NMR for identification. While comparative example 1 as shown below used DMF and Cu for coupling, obtaining extremely low yield, a substantial improvement was shown in the yield, with the yield of the target substance being 205.7 mg and 57% in the case where Cu2O was added and methoxyethanol was used for solvent, this time.
 

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