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Chemical Structure| 19380-80-4 Chemical Structure| 19380-80-4

Structure of 19380-80-4

Chemical Structure| 19380-80-4

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Product Details of [ 19380-80-4 ]

CAS No. :19380-80-4
Formula : C8H9ClN2S
M.W : 200.69
SMILES Code : S=C(N)NCC1=CC=CC=C1Cl

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Application In Synthesis of [ 19380-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19380-80-4 ]

[ 19380-80-4 ] Synthesis Path-Downstream   1~1

  • 1
  • ammonium thiocyanate [ No CAS ]
  • [ 19380-80-4 ]
  • [ 22680-44-0 ]
  • [ 106-94-5 ]
  • [ 141771-20-2 ]
YieldReaction ConditionsOperation in experiment
In water; toluene; acetonitrile; (ii) 1-(2-chlorophenyl)methyl-2-propyl-2-thiopseudourea A solution of <strong>[22680-44-0]2-chlorobenzylamine hydrochloride</strong> (41 g, 0.23 mol) and ammonium thiocyanate (19.28 g, 0.253 mol) in water (170 mL) was heated on the steam bath for 18 hours. This mixture was concentrated in vacuo, and the residue was taken up in toluene (1 L) and azeotroped with a Dean-Stark head. The residue was triturated with wet diethyl ether to provide 27.6 g (60%) of 1-(2-chlorophenyl)methyl thiourea. The product was recrystallized from ethanol; mp 120-122 C. A mixture of 1-(2-chlorophenyl)methyl thiourea (3 g, 14.9 mmol) and propylbromide (13.5 g, 110 mmol) in acetonitrile (20 mL) was refluxed for 5 hours. The solvent was evaporated, the residue was dissolved in 200 mL of 50% water/ether and acidified with 48% hydrobromic acid solution. The two phases were separated, the aqueous layer was washed with ether and then the aqueous layer was basified with 10% sodium carbonate solution. The liberated product was extracted with diethyl ether, washed with water and brine, dried and concentrated to give 1-(2-chlorophenyl)methyl-2-propyl-2-thiopseudourea (2.82 g, 78%); mp 112-114 C.
 

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