19181-54-5|8-Methylquinazolin-4(3H)-one| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 19181-54-5 ] Purity: 97% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 19181-54-5 ]

CAS No. :	19181-54-5
Formula :	C₉H₈N₂O
M.W :	160.17
SMILES Code :	O=C1NC=NC2=C1C=CC=C2C
MDL No. :	MFCD01685945
InChI Key :	GZRXSFZDLGKFLN-UHFFFAOYSA-N
Pubchem ID :	135471300

Safety of [ 19181-54-5 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Computational Chemistry of [ 19181-54-5 ] Show Less

Physicochemical Properties

Num. heavy atoms	12
Num. arom. heavy atoms	10
Fraction Csp3	0.11
Num. rotatable bonds	0
Num. H-bond acceptors	2.0
Num. H-bond donors	1.0
Molar Refractivity	47.33
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	45.75 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.39
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.07
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	1.23
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	1.44
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.54
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.53

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-2.12
Solubility	1.2 mg/ml ; 0.00752 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.62
Solubility	3.82 mg/ml ; 0.0239 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-3.61
Solubility	0.0392 mg/ml ; 0.000245 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.52 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.42

Application In Synthesis of [ 19181-54-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 19181-54-5 ]

[ 19181-54-5 ] Synthesis Path-Downstream 1~35

1
[ 19181-54-5 ]
[ 100524-99-0 ]
[ 112274-78-9 ]

References: [1]Journal of Organic Chemistry,1952,vol. 17,p. 149,153.

2
[ 58421-80-0 ]
[ 19181-54-5 ]

References: [1]Chemische Berichte,1905,vol. 38,p. 3561.

3
[ 4389-45-1 ]
[ 77287-34-4 ]
[ 19181-54-5 ]

Yield	Reaction Conditions	Operation in experiment
86%	With formamidine acetic acid; at 160℃; for 16h;	2-Amino-3-methylbenzoic acid (100 g, 0.66 mol), formamidine acetate (206 g, 1 .98 mol) and formamide (26 mL, 0.6600 mol) were mixed in a 2L R.B fitted with Mechanical stirrer. The reaction mixture was heated at 160 C for 16h. The reaction completion was monitored by LCMS. After completion, the reaction mixture was cooled to was RT and diluted with 2N NaOH solution (300 mL). After stirring at the same temperature for 15min, the reaction mixture neutralised with 1.5N HCI solution. The solid precipitated was filtered off, washed with ice cold water and dried under vacuum to yield (90 g, 86% yield) of the titled compound as an off white solid. H NMR (DMSO-d6, 400MHz) delta 12.21 ( bs, 1 H), 8.10 (s, 1 H), 7.95-7.93 (dd, J = 8.8, 7.9 Hz, 1 H), 7.65-7.63 (d, J = 7.9 Hz, 1 H), 7.39-7.35 (t, J = 15.2 Hz, 1 H), 2.51 (s, 3H).
78%	at 140℃;	General procedure: To a three necked flask, substituted anthranilic acid (1 meq.) was added in excess of formamide (6 meq). The reaction mixture was then heated at 140 C for 4-6 h. The reaction was monitored with thin layer chromatography and upon completion; ice was added to the reaction mixture. The resultant solid was filtered, washed with water, dissolved in ethyl acetate, dried over MgSO4 and concentrated to obtain the pure desired product. Where product did not precipitate on addition of ice, the reaction mixture was extracted with ethyl acetate, dried over MgSO4 and concentrated to obtain the desired quinazolin-4(3H)-one derivatives 1-9, 11-15, 17-21 and 23-25.The amino derivatives 10, 16 and 22 were prepared using the following general procedure:To a reaction flask, substituted nitroquinazolin-4(3H)-one derivative (0.3 g, 1.56 mmol) was added followed by addition of 6 mL ethyl acetate and SnCl2·2H2O (2.12 g, 9.42 mmol), then reaction mixture was refluxed for 8 h. The reaction mixture was cooled to room temperature and quenched with saturated sodium bicarbonate solution, followed by repeated extraction with ethyl acetate (3 × 50 mL). The organic layers were combined, dried over anhydrous MgSO4 and concentrated to obtain the desired amino substituted quinazolin-4(3H)-one derivatives 10, 16 and 22.The substituted anthranilic acid (1 g) was dissolved in excess acetic anhydride (10 mL) and the resulting reaction mixture was stirred at room temperature for 4-7 h. The reaction was monitored for completion using thin layer chromatography. The solvent was evaporated under vacuum and the resultant residue was stirred with ammonia solution for 7 h. Upon completion, the reaction mixture was extracted with ethyl acetate (3 × 10 mL), the organic extracts were combined, dried over MgSO4 and evaporated to obtain compounds 26-30, 31a and 32. The 2-methyl-8-nitroquinazolin-4(3H)-one intermediate (31a) was reduced to compound 31 using the same procedure as reported in Scheme 1 for the synthesis of compounds 10, 16 and 22.
	at 130 - 135℃; for 4h;	General procedure: Compound 18 was prepared accordingto the procedure previously reported.39 A mixture of anthranilicacid 11 (0.1 mol) and formamide (18 g, 0.4 mol) was heated at130-135 C. After the mixture had been stirred for 4 h, water(40 mL) was added. The reaction mixture was cooled to 60 C,and water (20 mL) was added to the mixture. After the mixturehad been stirred for 30 min, the precipitated product wasfiltered off with suction. The crude products were recrystallizedwith ethanol to give compound 18 in yields of 80-95%.

References: [1]Patent: WO2013/96194,2013,A1 .Location in patent: Page/Page column 28-29.
[2]European Journal of Medicinal Chemistry,2012,vol. 50,p. 264 - 273.
[3]Journal of Medicinal Chemistry,2016,vol. 59,p. 2794 - 2809.
[4]Chemische Berichte,1905,vol. 38,p. 3555.
[5]Journal of Organic Chemistry,1952,vol. 17,p. 149,153.
[6]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 1203 - 1207.
[7]European Journal of Medicinal Chemistry,2013,vol. 63,p. 662 - 669.
[8]Medicinal Chemistry Research,2014,vol. 23,p. 2584 - 2595.
[9]Journal of Agricultural and Food Chemistry,2014,vol. 62,p. 8928 - 8934.
[10]Biochemistry,2017,vol. 56,p. 6491 - 6502.

4
[ 19181-54-5 ]
[ 75844-43-8 ]

References: [1]Tetrahedron Letters,1980,vol. 21,p. 3029 - 3032.

5
[ 19181-54-5 ]
[ 70-11-1 ]
8-Methyl-3-(2-oxo-2-phenyl-ethyl)-3H-quinazolin-4-one [ No CAS ]

References: [1]Polish Journal of Chemistry,1997,vol. 71,p. 57 - 62.

6
[ 19181-54-5 ]
[ 536-38-9 ]
3-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-8-methyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Polish Journal of Chemistry,1997,vol. 71,p. 57 - 62.

7
[ 19181-54-5 ]
[ 99-73-0 ]
3-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-8-methyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Polish Journal of Chemistry,1997,vol. 71,p. 57 - 62.

8
[ 19181-54-5 ]
[ 31827-94-8 ]
3-[2-(4-Iodo-phenyl)-2-oxo-ethyl]-8-methyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Polish Journal of Chemistry,1997,vol. 71,p. 57 - 62.

9
[ 19181-54-5 ]
[ 58421-80-0 ]

Yield	Reaction Conditions	Operation in experiment
86%	With trichlorophosphate; at 120℃; for 12h;Inert atmosphere;	Phosphorous oxychloride (800 mL) was taken in a 2 L round bottom flask under nitrogen. To this was added 8-Methylquinazolin-4(3H)-one (125 g) in portions. The reactionminxture refluxed at 120 C for 12h. Reaction completion was monitored by TLC and LCMS. After completion, the reactionminxture was cooled to RT and evaporated to dryness under reduced pressure. The resulted residue was dissolved in DCM (500 mL) and quenched slowly into an ice cold solution of saturated K2C03 with constant stirring. Then the organic layer was separated and washed with brine solution, dried over sodium sulfate and concentrated under vacuum to afford 4-chloro-8-methylquinazoline (120 g, 86%) as yellow solid. This was taken for next step without further purification. MS: m/z = 179/18 1 [M+Hj.
35%	With trichlorophosphate; In acetonitrile;Reflux;	b. Preparation of Compound 12b To a solution of 8-methylquinazolin-4(3H)-one 12a (1.1 g, 6.92 mmol) in 155 ml ACN was added 10.1 mL POCl3. The reaction mixture is refluxed until completion, cooled to room temperature. The solvent was removed under vacuum, and the crude product was purified in ISCO using Ethyl acetate: hexane solvent system to afford the pure product (430 mg, 35% yield). 1H NMR (CDC13, 400 MHz) delta 9.06 (s, 1H), 8.12 (d, J= 8.4 Hz, 1H), 7.80 (d, J = 6.9 Hz, 1H), 7.61 (m, 1H), 2.78 (s, 3H).
35%	With trichlorophosphate; In acetonitrile;Reflux;	To a solution of 8-methylquinazolin-4(3H)-one 12a (1.1 g, 6.92 mmol) in 155 ml ACN was added 10.1 mE P0C13. The reaction mixture is refluxed until completion, cooled to room temperature. The solvent was removed under vacuum, and the crude product was purified in ISCO using Ethyl acetate:hexane solvent system to afford the pure product (430 mg, 35% yield). 1H NMR (CDCl3, 400 MHz) oe 9.06 (s, 1-H), 8.12 (d, J=8.4 Hz, 1H), 7.80 (d, J=6.9 Hz, 1-H), 7.61 (m, 1H), 2.78 (s, 3H).

	With trichlorophosphate; at 120℃; for 12h;Inert atmosphere;	POCI3 (300 mL) was taken in a 2 L round bottom flask under nitrogen. To this was added 8-Methylquinazolin-4(3H)-one (45 g) in portions. The reaction mixture refluxed at 120 C for 12h. Reaction completion was monitored by TLC and LCMS. After completion, the reaction mixture was cooled to RT and evaporated to dryness under reduced pressure. The resulted residue was dissolved in DCM (500 mL) and quenched slowly into an ice cold solution of saturated K2C03 with constant stirring. Then the organic layer was separated and washed with brine solution, dried over sodium sulphate and concentrated under vacuum to afford (45g, 90% yield) of the titled compound as yellow solid. This was taken for next step without further purification. H NMR (CDCI3, 400MHz) delta 9.03 (s, 1 H), 8.08-8.06 (dd, J = 8.9, 8.4 Hz, 1 H), 7.77-7.76 (d, J = 7.1 Hz, 1 H), 7.59-7.56 (d, J = 15.5 Hz, 1 H), 2.75 (s, 3H).
	With thionyl chloride; N,N-dimethyl-formamide; for 8h;Reflux;	General procedure: A mixture of 4-quinazolone analogues 2a-2j (8.0 mmol) in SOCI2 (27.4 mL) containing DMF (2 drops) was refluxed for 8 h. SOCI2 was removed under reduced pressure and the residue was dissolved in DCM. The solution was washed with saturated NaHCO3 solution and brine, respectively, dried over anhydrous Na2S04 and then concentrated under reduced pressure to yield the compounds 3a-3j (65.1-88.9percent yield) as white or off-white solid.
	With thionyl chloride; In N,N-dimethyl-formamide; for 5h;Reflux;	General procedure: A mixture of 4-hydroxyquinazoline (0.02 mol) in SOCl2 (20 mL)containing DMF (2 drops) was refluxed for 5 h. SOCl2 was removedunder reduced pressure, and the residue was dissolved in dichloromethane(DCM). The solution was washed with NaHCO3 solutionand brine, dried over anhydrous Na2SO4, and concentrated under reducedpressure to obtain the desired compound as a yellow solid.

References: [1]Patent: WO2017/106607,2017,A1 .Location in patent: Paragraph 00224.
[2]Synthetic Communications,2011,vol. 41,p. 3644 - 3653.
[3]Patent: WO2013/106756,2013,A2 .Location in patent: Page/Page column 40.
[4]Patent: US9822108,2017,B2 .Location in patent: Page/Page column 42.
[5]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 1203 - 1207.
[6]Organic Letters,2010,vol. 12,p. 552 - 555.
[7]Patent: WO2013/96194,2013,A1 .Location in patent: Page/Page column 29.
[8]European Journal of Medicinal Chemistry,2013,vol. 63,p. 662 - 669.
[9]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 4968 - 4974.
[10]Medicinal Chemistry Research,2014,vol. 23,p. 2584 - 2595.
[11]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 4885 - 4888.
[12]Bioorganic Chemistry,2018,vol. 80,p. 433 - 443.

Yield	Reaction Conditions	Operation in experiment
98%	With ammonium hydroxide; palladium dichloride; at 90℃; for 0.166667h;Microwave irradiation;	General procedure: (1) adding palladium chloride 0.2 mmol to the microwave reaction tube,2-iodobenzoic acid 1 mmol,Hydrogen cyanide1.2 mmol and 2 ml 25-28% ammoniaWater, then at 120w,The reaction was carried out at 90 C for 10 min.The product was purified by column chromatography to give a white solid.The yield was 96%.(2) The 2-iodobenzoic acid in (1) was replaced with 2-bromobenzoic acid in a yield of 94%.
98%	With ammonium hydroxide; palladium dichloride; at 90℃; for 0.166667h;Microwave irradiation;	General procedure: (1) adding palladium chloride 0.2 mmol to the microwave reaction tube,2-iodobenzoic acid 1 mmol,Hydrogen cyanide1.2 mmol and 2 ml 25-28% ammoniaWater, then at 120w,The reaction was carried out at 90 C for 10 min.The product was purified by column chromatography to give a white solid.The yield was 96%.(2) The 2-iodobenzoic acid in (1) was replaced with 2-bromobenzoic acid in a yield of 94%.
92%	In 2-methoxy-ethanol; at 100℃;	General procedure: To a solution of 2-amino-4, 5-dimethoxybenzoic acid (5.0 g, 25.4 mmol) in 100 mL of 2- methoxyethanol was added formamidine acetate (4.0 g, 38.0 mmol). The resulting mixture was stirred at 100 C for overnight. After cooled to room temperature, the solvent was removed in vacuo and the residue was diluted with 150 mL of ammonium hydroxide (10% water solution). The precipitated solid was collected by filtration and the filter cake was washed with water and dried in air to give 4.70 g (88%) of the title compound as a dark brown solid. MS (ESIpos): m/z = 207 (M+H)+. LC-MS [Method 2]: Rt = 1.12 min.

91%	With ammonium hydroxide; palladium dichloride; at 90℃; for 0.166667h;Microwave irradiation; Green chemistry;	General procedure: (1) Adding 0.2 mmol of palladium chloride and 1 mmol of 2-iodobenzamide to the microwave reaction tube. 1.2 mmol of hydrogen cyanide 2 ml of ammonia water, then reacted at 120 w, 90 C for 10 minutes. The product was extracted with ethyl acetate and concentrated under reduced pressure, The product was purified by column chromatography to give a white solid. The yield was 96%. (2) The 2-iodobenzamide in (1) was replaced with 2-bromobenzamide in a yield of 94%.
90%	With ammonium hydroxide; palladium dichloride; at 90℃; for 0.166667h;Microwave irradiation; Green chemistry;	General procedure: (1) Adding 0.2 mmol of palladium chloride and 1 mmol of 2-iodobenzamide to the microwave reaction tube. 1.2 mmol of hydrogen cyanide 2 ml of ammonia water, then reacted at 120 w, 90 C for 10 minutes. The product was extracted with ethyl acetate and concentrated under reduced pressure, The product was purified by column chromatography to give a white solid. The yield was 96%. (2) The 2-iodobenzamide in (1) was replaced with 2-bromobenzamide in a yield of 94%.

11
[ 19181-54-5 ]
[ 304665-10-9 ]
(2R,3S)-3-Benzyloxy-2-[2-hydroxy-3-(8-methyl-4-oxo-4H-quinazolin-3-yl)-propyl]-piperidine-1-carboxylic acid benzyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1854 - 1858.

12
[ 19181-54-5 ]
3-[3-((2R,3S)-3-Hydroxy-piperidin-2-yl)-2-oxo-propyl]-8-methyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1854 - 1858.

13
[ 19181-54-5 ]
(2R,3S)-3-Benzyloxy-2-[3-(8-methyl-4-oxo-4H-quinazolin-3-yl)-2-oxo-propyl]-piperidine-1-carboxylic acid benzyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1854 - 1858.

14
[ 19181-54-5 ]
3-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-8-methyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Polish Journal of Chemistry,1997,vol. 71,p. 57 - 62.

15
[ 19181-54-5 ]
(3-Chloro-phenyl)-(8-methyl-quinazolin-4-yl)-amine; hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 1203 - 1207.

16
[ 19181-54-5 ]
3-[3-(3-methoxy-[2]piperidyl)-2-oxo-propyl]-8-methyl-3<i>H</i>-quinazolin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1952,vol. 17,p. 149,153.

17
[ 19181-54-5 ]
3-[3-(3-hydroxy-[2]piperidyl)-2-oxo-propyl]-8-methyl-3<i>H</i>-quinazolin-4-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1952,vol. 17,p. 149,153.

18
[ 5437-38-7 ]
[ 19181-54-5 ]

References: [1]Chemische Berichte,1905,vol. 38,p. 3555.

19
[ 620-22-4 ]
[ 19181-54-5 ]

References: [1]Chemische Berichte,1905,vol. 38,p. 3555.

20
[ 99-04-7 ]
[ 19181-54-5 ]

References: [1]Chemische Berichte,1905,vol. 38,p. 3555.

21
[ 4389-45-1 ]
[ 19181-54-5 ]

Yield	Reaction Conditions	Operation in experiment
	With formamide;	Step A Preparation of 8-methylquinazolin-4(3H)-one 2-Amino-3-methylbenzoic acid (1.00 g, 0.0066 mol) and formamide (12 mL) were heated together at 130 C. for 20 hr. under nitrogen. After cooling to room temperature, the solid was filtered off, washed with diethyl ether and dried in vacuo to leave 8-methylquinazolin-4(3H)-one (1.19 g). 1 H-NMR 400 MHz (CD3 OD): delta 8.06 (m, 2H), 7.68 (d, 1H), 7.41 (t, 1H), 2.59 (s, 3H); EI-MS 160 (M+).

References: [1]Patent: US5401745,1995,A .

22
[ 887234-41-5 ]
[ 463-52-5 ]
[ 19181-54-5 ]

References: [1]Synthesis,2008,p. 3974 - 3980.

23
[ 19181-54-5 ]
[ 1276665-93-0 ]

References: [1]Tetrahedron,2011,vol. 67,p. 1665 - 1672.

24
[ 19181-54-5 ]
C₉H₇Cl₅N₅OP₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20℃; for 20h;Inert atmosphere;	General procedure: Quinazolin-4(3H)-ones (3, 0.5 mmol), HCCP (173.9 mg, 0.5 mmol, 1 equiv), DIPEA (323.8 mg, 2.5 mmol, 5 equiv), and MeCN (2 mL) were added to a nitrogen purged vial. The reaction mixture was stirred at room temperature for 1 h as activation time. The reactions were monitored by TLC. Then N-containing nucleophile (3.0 mmol, 6 equiv) was added, and the reaction mixture was stirred at room temperature for an appropriate time. After the mixture was concentrated under reduced pressure, the residue was purified by chromatography on silica gel to afford the corresponding products 4-aminoquinazolines (4-29).

References: [1]Tetrahedron,2011,vol. 67,p. 1665 - 1672.

25
[ 19181-54-5 ]
[ 1293384-20-9 ]

References: [1]Journal of Chemical Research,2011,vol. 35,p. 4 - 7.

26
[ 19181-54-5 ]
[ 106-93-4 ]
[ 1293384-29-8 ]

References: [1]Journal of Chemical Research,2011,vol. 35,p. 4 - 7.

27
[ 18503-89-4 ]
[ 1885-32-1 ]
[ 19181-54-5 ]
[ 1332493-28-3 ]
[ 1332493-36-3 ]
[ 1332493-35-2 ]

References: [1]Organic and Biomolecular Chemistry,2011,vol. 9,p. 6089 - 6099.

28
[ 4389-45-1 ]
[ 19181-54-5 ]
[ 1332493-28-3 ]
[ 1332493-36-3 ]
[ 1332493-35-2 ]

References: [1]Organic and Biomolecular Chemistry,2011,vol. 9,p. 6089 - 6099.

29
[ 19181-54-5 ]
[ 100-46-9 ]
[ 1258431-81-0 ]

References: [1]Synthetic Communications,2011,vol. 41,p. 3644 - 3653.

30
[ 19181-54-5 ]
[ 1449109-06-1 ]

References: [1]Molecules,2013,vol. 18,p. 5580 - 5593.

31
[ 19181-54-5 ]
[ 58421-82-2 ]

References: [1]Molecules,2013,vol. 18,p. 5580 - 5593.

32
[ 940-71-6 ]
[ 19181-54-5 ]
C₉H₇Cl₅N₅OP₃ [ No CAS ]

References: [1]Molecules,2013,vol. 18,p. 5580 - 5593.

33
[ 19181-54-5 ]
C₂₄H₂₁FN₆O₅S [ No CAS ]

References: [1]Patent: WO2013/96194,2013,A1 .

34
[ 19181-54-5 ]
[ 1445781-41-8 ]

References: [1]Patent: WO2013/96194,2013,A1 .
[2]Patent: WO2017/106607,2017,A1 .

35
[ 19181-54-5 ]
[ 1445781-42-9 ]

References: [1]Patent: WO2013/96194,2013,A1 .
[2]Patent: WO2017/106607,2017,A1 .

Historical Records

Technical Information

• Acyl Group Substitution • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hydride Reductions • Lawesson's Reagent • Preparation of Amines • Reactions of Amines • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes

Related Functional Groups of
[ 19181-54-5 ]

Amides

A215736 [75844-40-5]

7-Methylquinazolin-4(3H)-one

Similarity: 0.97

A145794 [17329-31-6]

6-Aminoquinazolin-4(3H)-one

Similarity: 0.95

A354609 [117297-41-3]

4-oxo-3,4-Dihydroquinazoline-6-carbonitrile

Similarity: 0.90

A141344 [109229-22-3]

6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

Similarity: 0.88

A125178 [202197-73-7]

4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid

Similarity: 0.84

Related Parent Nucleus of
[ 19181-54-5 ]

Quinazolines

A215736 [75844-40-5]

7-Methylquinazolin-4(3H)-one

Similarity: 0.97

A145794 [17329-31-6]

6-Aminoquinazolin-4(3H)-one

Similarity: 0.95

A354609 [117297-41-3]

4-oxo-3,4-Dihydroquinazoline-6-carbonitrile

Similarity: 0.90

A125178 [202197-73-7]

4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid

Similarity: 0.84

A235892 [194851-16-6]

7-Bromoquinazolin-4(3H)-one

Similarity: 0.83

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

{[proInfo.proName]}

CAS No.: 19181-54-5

{[proInfo.proName]}