19036-43-2|3-Amino-2,2-dimethylpropanoic acid| Ambeed

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CAS No. :	19036-43-2
Formula :	C₅H₁₁NO₂
M.W :	117.15
SMILES Code :	CC(C)(CN)C(O)=O
MDL No. :	MFCD09055365
InChI Key :	DGNHGRLDBKAPEH-UHFFFAOYSA-N
Pubchem ID :	95739

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H312-H332
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501

Yield	Reaction Conditions	Operation in experiment
91%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60℃; for 16h;	Example 6: Synthesis of 3-(tert-butoxycarbonylamino)-2,2-dimethylpropanoic acid (19)[00156] 3-Amino-2,2-dimethylpropanoic acid (18) (1.2 g, 10.2 mmol), Boc anhydride (2.3 g, 10.2 mmol) and DIPEA (1.85 mL, 10.23 mmol) were stirred under argon in DMF (30 mL) at 60 C for 16 h. The reaction was concentrated in vacuo, taken up in EtOAc, washed with saturated NH4C1 solution, and concentrated in vacuo to give 3-(teri-butoxycarbonylamino)-2,2-dimethylpropanoic acid (19) (2.0 g, 91 %); 1H NMR (300 mHz - CDCl3) 6 1.33 (s, 6 H), 1.37 (s, 9 H), 2.69 (s, 2 H).
63%	With sodium hydroxide; In water; tert-butyl alcohol; at 20℃; for 16h;	Preparational Example 21 Preparation of 3-(t-butoxycarbonylamino)-2,2-dimethylpropanoic acid 256 mg (2.22 mmol) of the -amino-2,2-dimethylpropanoic acid prepared in Preparational Example 20 was dissolved in 2.0 ml of water and 3.0 ml of t-BuOH, to which 4.0 ml of 1.0 N NaOH solution and 725 mg (3.32 mmol) of Boc2O were added. The mixture was stirred at room temperature for 16 hours, followed by evaporation under reduced pressure to eliminate the solvent. The residue was acidized with 1 N HCl to be pH 3, followed by extraction with 320 ml of ethyl acetate. The extract was dried over anhydrous magnesium sulfate, followed by evaporation under reduced pressure to give 305 mg of 3-(t-butoxycarbonylamino)-2,2-dimethylpropanoic acid (yield: 63%). 1H NMR (400 MHz, CDCl3) delta 3.25 (s, 2H), 1.44 (s, 9H), 1.18 (s, 6H)
63%	With sodium hydroxide; In water; tert-butyl alcohol; at 20℃; for 16h;	256 mg (2.22 mmol) of the -amino-2,2-dimethylpropanoic acid prepared in Preparational Example 20 was dissolved in 2.0 ml of water and 3.0 ml of t-BuOH, to which 4.0 ml of 1.0 N NaOH solution and 725 mg (3.32 mmol) of Boc2O were added. The mixture was stirred at room temperature for 16 hours, followed by evaporation under reduced pressure to eliminate the solvent. The residue was acidized with 1 N HCl to be pH 3, followed by extraction with 320 ml of ethyl acetate. The extract was dried over anhydrous magnesium sulfate, followed by evaporation under reduced pressure to give 305 mg of 3-(t-butoxycarbonylamino)-2,2-dimethylpropanoic acid (yield: 63%). 1H NMR (400 MHz, CDCl3) delta 3.25 (s, 2H), 1.44 (s, 9H), 1.18 (s, 6H)

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CAS No.: 19036-43-2

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CAS No.: 19036-43-2

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[ 19036-43-2 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed