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Chemical Structure| 190273-89-3 Chemical Structure| 190273-89-3

Structure of 190273-89-3

Chemical Structure| 190273-89-3

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Product Details of [ 190273-89-3 ]

CAS No. :190273-89-3
Formula : C8H6BrN3
M.W : 224.06
SMILES Code : NC1=NC=C2C=C(Br)C=CC2=N1
MDL No. :MFCD04114089
InChI Key :IJXKEDDKGGBSBX-UHFFFAOYSA-N
Pubchem ID :2762768

Safety of [ 190273-89-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 190273-89-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 190273-89-3 ]

[ 190273-89-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 89694-46-2 ]
  • [ 190273-89-3 ]
  • [ 1234096-83-3 ]
YieldReaction ConditionsOperation in experiment
61% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere; Synthesis of intermediate 2 6-(2-Chloro-5-methoxy~phenyi)-quinazolin-2- ylamine; To a solution of 2-chloro-5-methoxy boronic acid (14.42g, 77.34 mmol, 1.5eq), 6-Bromo-quinazolin~2~ylamine ( 11.55g, 51.56 mmol, leq) and Na2CO3 (21.86g, 206.23 mmol, 4eq) in a mixture of 120ml DMF/3ml EtOH/30m. H2O, was added 2.311g (5.16 mmol, 0.1 eq) of tetrakis(tpiphenylphospine) palladium. The reaction was refluxed(1000C) for 2 hours under argon. It was then cooled off to room temperature to extract the product by DCM and brine. The product is then washed with water and ether, then dried to give 9.010 g (32 mmol, 61percent) of a pale yellow powder.
  • 2
  • [ 89694-46-2 ]
  • [ 190273-89-3 ]
  • [ 1239954-94-9 ]
YieldReaction ConditionsOperation in experiment
61% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; N,N-dimethyl-formamide; at 100℃; for 2h;Inert atmosphere; Method 2:Synthesis of intermediate 5: 6-(2-Chloro-5-methoxy-phenyl)-quinazolin-2- ylamineTo a solution of 2-chloro-5-methoxy boronic acid (14.42g, 77.34 mmol, 1 .5eq), 6-Bromo-quinazolin-2-ylamine (1 1 .55g, 51 .56 mmol, 1 eq) and Na2C03 (21 .86g, 206.23 mmol, 4eq) in a mixture of 120ml DMF/30ml EtOH/30ml H20, was added 2.31 1 g (5.16 mmol, 0.1 eq) of tetrakis(triphenylphospine) palladium. The reaction was refluxed (Iota OmicronOmicron ') for 2 hours under argon. It was then cooled off to room temperature to extract the product by DCM and brine. The product is then washed with water and ether, then dried to give 9.010 g (32 mmol, 61 percent) of a pale yellow powder.
  • 3
  • [ 190273-89-3 ]
  • [ 458532-98-4 ]
  • 6-(3-chloropyridin-4-yl)quinazolin-2-amine [ No CAS ]
 

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Technical Information

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[ 190273-89-3 ]

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Related Parent Nucleus of
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