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Chemical Structure| 1897-50-3 Chemical Structure| 1897-50-3

Structure of 1897-50-3

Chemical Structure| 1897-50-3

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Product Details of [ 1897-50-3 ]

CAS No. :1897-50-3
Formula : C8ClF3N2
M.W : 216.55
SMILES Code : N#CC1=C(F)C(Cl)=C(F)C(C#N)=C1F
MDL No. :MFCD06658269

Safety of [ 1897-50-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1897-50-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1897-50-3 ]

[ 1897-50-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1897-50-3 ]
  • [ 27757-86-4 ]
  • 5-chloro-2,4-fluoro-6-((thiophen-3-methyl)amino)isophthalonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% In tetrahydrofuran; at 30℃; for 0.5h; The raw material 5-chloro-2,4,6-trifluoro-isophthalonitrile was added to a 25 mL round bottom flask at 30 C,Add tetrahydrofuran to dissolve and stir (ie, with tetrahydrofuran)Furan as solvent), tetrahydrofuran volume and 5-chloro_2,4,6-trifluoro-isophthalonitrile molar ratio of 15mL / lmmol, the raw materialsThiophene-3-methylamine was slowly added dropwise.(2,4_-difluorophenyl) methylamine with 2,4,5,6_ tetrafluorophthalonitrile was 1.2:1. TLC detection reaction at any time, 30min reaction is complete, immediately add the same volume of solvent ice water quenching, with the same volume of solvent BEthyl acetate extraction three times, take the organic layer, extract with anhydrous Na2S04 after drying, followed by suction filtration, the filtrate concentrated evaporated,The mobile phase was petroleum ether and ethyl acetate 15: 1 ratio, the column chromatography separation, the product Rf value of 0.3, driedYellow solid product 5-Chloro-2,4-fluoro-6 - ((thiophene-3-methyl) amino) isophthalonitrile (Compound 5) in 85% yield.
 

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