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Chemical Structure| 185026-97-5 Chemical Structure| 185026-97-5

Structure of 185026-97-5

Chemical Structure| 185026-97-5

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Product Details of [ 185026-97-5 ]

CAS No. :185026-97-5
Formula : C11H19NO5
M.W : 245.27
SMILES Code : O=C(N1[C@@](C(O)=O)(C)C[C@@H](O)C1)OC(C)(C)C
MDL No. :N/A

Safety of [ 185026-97-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 185026-97-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 185026-97-5 ]

[ 185026-97-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38222-83-2 ]
  • [ 3695-77-0 ]
  • [ 185026-97-5 ]
  • [S-(R*,R*)]-4-[(Triphenylmethyl)thio]-1,2-pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With trifluoromethylsulfonic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; A. [S-(R*,R*)]-4-[(Triphenylmethyl)thio]-1,2-pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester To a solution of [R-(R*,S*)]-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester (2.0 g, 8.2 mmol) and <strong>[38222-83-2]2,6-di-tert-butyl-4-methylpyridine</strong> (1.7 g, 8.2 mmol) in methylene chloride (30 mL) at -40°C under nitrogen, was added triflic anhydride (1.5 mL, 8.9 mmol) dropwise via syringe over 15 minutes. The solution was stirred at -40°C for 0.5 hours and at 0°C for 1 hour. This solution was added slowly (over 0.5 hours) to a solution of triphenyl-methylmercaptan (5.5 g, 20 mmol) and lithium hexamethyldisilazide (1 Molar solution in THF, 20 mL, 20 mmol) in THF (10 mL) at 0°C. The resulting solution was stirred for 16 hours at room temperature. The solution was concentrated and the residue was chromatographed (260-400 mesh silica gel, 7.1 X 20 cm, 1:9-1:3/ethyl acetate:hexane). Fractions containing the desired product were collected and concentrated to yield 2.5 g of Compound A. MS (M+H)+ 504+.
 

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