Home Cart Sign in  
Chemical Structure| 183288-44-0 Chemical Structure| 183288-44-0

Structure of 183288-44-0

Chemical Structure| 183288-44-0

tert-Butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate

CAS No.: 183288-44-0

4.5 *For Research Use Only !

Cat. No.: A345042 Purity: 98%

Change View

Size Price

US Stock

Global Stock

In Stock
100mg ł§ÿ¶ÊÊ Inquiry Inquiry

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • 100mg

    ł§ÿ¶ÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 183288-44-0 ]

CAS No. :183288-44-0
Formula : C18H23N3O4
M.W : 345.39
SMILES Code : O=C(N1CCN(C2=CC=C(OC(C(N)=O)=C3)C3=C2)CC1)OC(C)(C)C
MDL No. :MFCD22208558

Safety of [ 183288-44-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 183288-44-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 183288-44-0 ]

[ 183288-44-0 ] Synthesis Path-Downstream   1~2

  • 1
  • P(t-Bu)3 [ No CAS ]
  • t-OBu [ No CAS ]
  • [ 35351-21-4 ]
  • [ 57260-71-6 ]
  • [ 183288-44-0 ]
  • [ 183288-46-2 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride;Pd(dba)2; In diethylene glycol dimethyl ether; water; 1) Synthesis of 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide from 5-bromobenzofuran-2-carboxamide 0.9 g of 5-bromobenzofuran-2-carboxamide, 1.1 g of BOC-piperazine and 1.45 g of Na t-OBu are added to a suspension of 0.06 g of Pd(DBA)2 and 0.25 g of P(t-Bu)3 in 40 ml of diethylene glycol dimethyl ether, and the mixture is warmed at 120-130 C. for 16 hours under a protective gas. After cooling, the mixture is added to water, and the organic phase is diluted with 100 ml of MTBE and washed with 3*50 ml of water. The solvent is evaporated, and the product formed as a solid is filtered off and purified by crystallization from ethanol (product weight: 0.7 g/55%/m.p. 210-213). The subsequent removal of the BOC protecting group using hydrochloric acid and formation of 5-(1-piperazinyl)benzofuran-2-carboxamide, which are shown below only as a reaction equation, can be carried out, for example, as described in GREENE T. W. and WUTS P. G. M., PROTECTIVE GROUPS IN ORGANIC SYNTHESIS.
  • 2
  • [ 183288-44-0 ]
  • [ 183288-46-2 ]
YieldReaction ConditionsOperation in experiment
In methanol hydrochloride; Example 6 1 g of 5-(4-tert-butoxycarbonyl-1-piperazinyl)-benzofuran-2-carboxamide is dissolved in 50 ml of methanolic HCl and stirred for I hour. After customary working up, 5-(1-piperazinyl)benzofuran-2-carboxamide, m.p. 252-255, is obtained.
 

Historical Records

Technical Information

Categories