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Chemical Structure| 18270-17-2 Chemical Structure| 18270-17-2

Structure of 18270-17-2

Chemical Structure| 18270-17-2

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Product Details of [ 18270-17-2 ]

CAS No. :18270-17-2
Formula : C8H16Si
M.W : 140.30
SMILES Code : CCCC#C[Si](C)(C)C
MDL No. :MFCD00077890

Safety of [ 18270-17-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 18270-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18270-17-2 ]

[ 18270-17-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 666746-27-6 ]
  • [ 18270-17-2 ]
  • (2-methyl-4-pent-1-ynyl-phenyl)-carbamic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl-ammonium chloride; silver carbonate; In tetrahydrofuran; at 60℃; for 20h;Inert atmosphere; Sealed tube; A vial charged with (4-iodo-2-methyl-phenyl)-carbamic acid tert-butyl ester (350 mg, 1.05 mmol), trimethyl -pent-l-ynyl-silane (290 mg, 2.1 mmol), Ag2CC>3 (290 mg, 1.05 mmol), (n-Bu)4N+CT (580 mg, 2.1 mmol) and Pd(PPh3)2Cl2 (70 mg, 0.1 mmol) in THF (12 mL) was bubbled with Ar for about 3 min and quickly sealed. The sealed vial was then heated at 60C for 20 h. The reaction mixture was filtered, and the filter cake was washed with EA (10 mL x 3). The filtrate and washings were combined and concentrated. The residue was purified by silica gel column chromatography (PE to PE/EA = 20/1) to give (2 -methyl -4-pent-l-ynyl-phenyl)-carbamic acid tert-butyl ester (200 mg, 70% yield) as a yellow solid. NMR (300 MHz, CDCh): d = 7.82 (d, J= 8.8 Hz, 1H), 7.27-7.11 (m, 2H), 6.29 (brs, 1H), 2.38 (t, J= 6.9 Hz, 2H), 2.21 (s, 3H), 1.72-1.58 (m, 2H), 1.53 (s, 9H), 1.05 (t, J= 7.2 Hz, 3H). MS: m/z 174.1 (M-100+H+ ).
 

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