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Chemical Structure| 18257-46-0 Chemical Structure| 18257-46-0

Structure of 18257-46-0

Chemical Structure| 18257-46-0

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Product Details of [ 18257-46-0 ]

CAS No. :18257-46-0
Formula : C5H13ClN2
M.W : 136.62
SMILES Code : CCCCC(N)=N.[H]Cl
MDL No. :MFCD11052491
InChI Key :FFHQVTXPIOPINO-UHFFFAOYSA-N
Pubchem ID :11615174

Safety of [ 18257-46-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 18257-46-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18257-46-0 ]

[ 18257-46-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 18257-46-0 ]
  • [ 146137-79-3 ]
  • 2-butyl-quinazoline-6-carbonitrile [ No CAS ]
  • 2
  • [ 32249-35-7 ]
  • [ 18257-46-0 ]
  • [ 1028727-26-5 ]
YieldReaction ConditionsOperation in experiment
78% With sodium methylate; In methanol; for 12h; To a solution of methyl 5-cyclopropyl-5-oxopropionate (2.39 g) and pentylamidine hydrochloride - (1.68 g) in methanol (20 mL) was added 28% sodium methoxide-methanol solution (5.27 mL), and the mixture was stirred for 12 hr. The reaction mixture was concentrated, and the residue was dissolved in water and diethyl ether. The aqueous layer was separated, and weakly acidified with 1 M hydrochloric acid. The precipitate was collected by filtration and dried under reduced pressure to give the title compound (2.02 g, 78%) as a colorless solid. 1H NMR (300 MHz, CDCl3) δ 0.87-0.99 (5H, m) , 1.01-1.10 (2H, m) , 1.29-1.46 (2H, m) , 1.61-1.85 (3H, m) , 2.61 (2H, t, J = 7.5), 6.15 (IH, s), 12.89 (IH, br)
 

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