Structure of 181219-01-2
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CAS No. : | 181219-01-2 |
Formula : | C11H16BNO2 |
M.W : | 205.06 |
SMILES Code : | C1=C(C=CN=C1)B2OC(C(O2)(C)C)(C)C |
MDL No. : | MFCD01319051 |
InChI Key : | NLTIETZTDSJANS-UHFFFAOYSA-N |
Pubchem ID : | 2734648 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302+H312+H332-H315-H319-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Num. heavy atoms | 15 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.55 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 3.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 60.71 |
TPSA ? Topological Polar Surface Area: Calculated from |
31.35 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
1.84 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
1.38 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.58 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.31 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.02 |
Log S (ESOL):? ESOL: Topological method implemented from |
-2.5 |
Solubility | 0.648 mg/ml ; 0.00316 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.12 |
Solubility | 1.56 mg/ml ; 0.0076 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.63 |
Solubility | 0.0481 mg/ml ; 0.000234 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
Yes |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
Yes |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.24 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
2.61 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium phosphate; lithium chloride;2?-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; at 100℃; for 0.5h;Microwave irradiation; | 1 g of tert-butyl 3-[(trifluoromethyl)sulfonyl]oxy}-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate, 0.975 g of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 0.24 g of lithium chloride, 1.78 g of potassium phosphate, 0.157 g of 2'-(dimethylamino)-2-biphenylpalladium(II)chloride dinorbornylphosphine and 10 ml of dioxane are introduced into an 80 ml glass tube. The tube is sealed and then heated at 100 C. under microwave irradiation for 30 minutes. Water and ethyl acetate are added. The aqueous phase is extracted three times with ethyl acetate. The organic phases are combined and dried over sodium sulfate and the solvent is evaporated off under reduced pressure. The residue is chromatographed on silica gel with a mixture of heptane/ethyl acetate. 0.458 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate is obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; at 100℃; for 24h;Inert atmosphere; | Step 5. Methyl 3-pyridin-4-yl-lH-indazole-5-carboxylate 4-(4;4?5,5-Tetramethyl-l53,2-dioxaborolan-2-yl)pyridine (0.965 g, 4.70 mmol), PdCl2(dppf)-CH2Cl (0.256 g, 0.314 mmol), sodium carbonate (3.14 mL, 6.27 mmol) and methyl 3-bromo-lH-indazole-5-carboxylate (0.8 g, 3.14 mmol) were taken up in 1,4-dioxane (15 mL). The flask was evacuated and back-filled with N2 (x3) before stirring at 100 C for 24 hours. Room temperature was attained, the reaction mixture was diltuted with MeOH, filtered through Celite and concentrated in vacuo.Purification of the residue by MPLC (12-100% EtOAc-hexanes) gave methyl 3- pyridin-4-yl-lH-indazole-5-carboxylate as a yellow solid.MS (APCI) calculated for Ci4Hi2N302 [M+H]+, 254; found 254 (0.92 mins). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | <a> Synthesis of Intermediate (44- 1) A flask was charged with 4,6-dichloropyridine (596 mg, 4.0 mmol), followed by being purged with argon gas. To the flask, thereafter, dioxane (60 mL), which had been deaerated with argon gas, 4-(4-pyridyl)phenyl boronic acid pinacol ester (4.0 mmol, 2.26 g), bis(triphenylphosphine) palladium(II) dichloride (0.3 mmol, 210 mg) were added. After bubbling the solution with argon gas, 2M K2CO3 (20 mL) was added, and the resultant was heated and stirred at 50C for 4 hours. Subsequently, 4-(4,4, 5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)pyridine (4 mmol, 820 mg) was added, and the resulting mixture was heated and stirred at 100C for 4 hours. The resultant was filtered with Celite, and water and chloroform were added to the filtrate to separate an organic layer. Thereafter, a water layer was extracted 5 times with chloroform. The combined organic layer was washed with saturated salt water, followed by drying with sodium sulfate to condensate the filtrate, to thereby obtain a crude product. The crude product was purified by silica-gel column chromatography (eluenf- chloroform/methanol = 93/7), and the obtained solids were dispersed and washed in chloroform/hexane. The solids were collected by filtration, and the obtained solids were vacuum dried to thereby obtain an intermediate (44- 1) as pale yellow solids (the yielded amount: 892 mg, the yield: 72%). NMR (500 MHz, CDCI3, delta) : 9.42 (d, J = 1.7 Hz, 1H), 8.85(dd, Ji = 5.8 Hz, J2 = 1.8 Hz, 2H), 8.73(dd, Ji = 6.3 Hz, J2 = 1.7 Hz, 2H), 8.31 (d, J =8.6 Hz, 2H), 8.2l(d, J = 1.7 Hz, 1H), 8.04 (dd, Ji = 6.3 Hz, J2 = 1.7 Hz, 2H), 7.84 (d, J =6.9 Hz, 2H), 7.59 (d, Ji = 5.8 Hz, J2 = 1.8 Hz, 2H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | <a> Synthesis of Intermediate (80- 1) Intermediate (80" l) A flask was charged with 2,4,6-trichloropyridine (732 mg, 4.0 mmol), followed by being purged with argon gas. To the flask, thereafter, dioxane (60 niL), which had been deaerated with argon gas, 4-(4-pyridyl)phenyl boronic acid pinacol ester (8.0 mmol, 2.26 g), and bis(triphenylphosphine)palladium(II) dichloride (0.3 mmol, 210 mg) were added. After bubbling the solution with argon gas, 2M K2CO3 (20 mL) was added, and the resultant was heated and stirred at 50C for 4 hours. Next, 4-4,4, 5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)pyridine (4 mmol, 820 mg) was added and the resultant was heated and stirred at 100C for 4 hours. Subsequently, the resultant was filtered with Celite, and water and chloroform were added to the filtrate to separate an organic layer. Thereafter, a water layer was extracted 5 times with chloroform. The combined organic layer was washed with saturated salt water, followed by drying with sodium sulfate to condensate the filtrate, to thereby obtain a crude product. The crude product was purified by silica-gel column chromatography (eluent: chloroform/methanol = 93/7), and the obtained solids were dispersed and washed in chloroform/hexane. The solids were collected by filtration, and the obtained solids were vacuum dried to thereby obtain an intermediate (80- 1) as pale yellow solids (the yielded amount: 1.19 g, the yield: 64% H NMR (500 MHz, CDCI3, delta) : 8.87 (dd, Ji = 4.7 Hz, J2 = 1.7 Hz, 2H), 8.75 (dd, Ji = 4.0 Hz, J2 = 1.7 Hz, 4H), 8.58 (dd, Ji = 4.7 Hz, J2 = 1.7 Hz, 2H), 8.45 (dt Ji = 8.0 Hz, J2 = 1.7 Hz, 4H), 8.21 (s, 1H), 7.88 (dd, Ji = 8.6 Hz, J2 = 1.7 Hz, 4H), 7.61 (dd, Ji = 4.7 Hz, J2 = 1.7 Hz, 4H) | |
61% | 2, 4, 6-trichloropyrimidine (732 mg, 4.0 mmol) was placed in a flask,After substitution with argon gas,Dioxane (60 mL) degassed with argon gas,4- (4-pyridyl) phenylboronic acid pinacol ester (8.0 mmol, 2.26 g) represented by the following structural formula (28)Bis (triphenylphosphine) palladium (II) dichloride (0.3 mmol, 210 mg) was added.After bubbling the solution with argon gas,2 M K 2 CO 3 (20 mL) was added,And the mixture was heated and stirred at 50 C. for 4 hours.Then 4- (4,4,5,5-tetramethyl-1,3,2-dioxeSabololan-2-yl) pyridine(4 mmol, 820 mg) was added,And the mixture was heated and stirred at 100 C. for 4 hours.Subsequently, the contents were filtered through celite, water and chloroform were added to the filtrate to separate the organic layer,The aqueous layer was extracted with chloroform.The combined organic layer was dried over sodium sulfate and the filtrate was concentrated to give a crude product.This was purified by silica gel chromatography (developing solvent: chloroform / methanol)The solid obtained after the concentration was dried under vacuum,The target compound was obtained as a pale yellow solid (yield 1.13 g, yield 61%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 60h; | In an exemplary set of experiments, ligand B-1 was prepared according to the method shown in Scheme 7. An exemplary 1H NMR spectrum (DMSO-d6, 400 MHz) is shown in FIG. 12. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 105℃; for 15h;Inert atmosphere; | In 100ml three-necked flask, 5,8-dibromo quinoxaline 1.00g (3.47mmol), 4- (4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine 3 .27g (15.97mmol), tetrakistriphenylphosphinepalladium 0.401g (0.347mmol), as a phase transfer catalyst, adding Aliquat336 (Aldrich) 0.150g (0.371mmol), after argon gas replacement, sequentially added degassed 1,4-dioxane 27ml and 1M- potassium carbonate aqueous solution 22ml with argon gas, after the reflux at 105 15 hours, the reaction solution after returning to room temperature, the chloroform and was added saturated brine . The solution was transferred to a separatory funnel, and the organic layer was washed with saturated brine, after dehydration by stirring at room temperature for 1 hour over magnesium sulfate as a drying agent to the organic layer, then palladium scavenger silica gel (Aldrich the Ltd.) was stirred for 1 hour at 2g was added at room temperature to remove residual palladium in the organic layer. After filtering off the drying agent and silica gel, and the solvent was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (toluene / acetone = 1/2) to obtain a desired product. The yield 0.78g, 79% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In 1,4-dioxane; water; at 80℃; for 3h;Inert atmosphere; | Intermediate 19A (504 mg, 1.77 mmol), 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan- 2-yl)pyridine (726 mg, 3.54 mmol), and sodium carbonate (375 mg, 3.54 mmol) were combined in dioxane (8 mL) and H20 (2 mL), and purged with nitrogen for 5 minutes. Pd(dppf)Cl2. CH2CI2 (145 mg, 0.180 mmol) was added, and the reaction was heated to 80C for three hours. The reaction was cooled to room temperature, and washed with H20. The solvent was removed in vacuo and the residue was purified by silica gel chromatography to afford Intermediate 19B (388 mg, 77%). LCMS (method A): m/z 285.2. 'H NMR (CDCI3): delta 8.67-8.66 (dd, 2H), 7.55-7.36 (m, 6H), 4.92-4.91 (br s, 1H), 4.41-4.40 (m, 2H), 1.48 (s, 9H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56.4% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; toluene; for 168h;Inert atmosphere; Reflux; | Example 26 Synthesis of 1,1',1"-trihexyl-[4,3':4',4"-terpyridine]-1,1',1"-triium tris(tetrafluoroborate) A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (2.32 g, 11.3 mmol), <strong>[13534-90-2]3,4-dibromopyridine</strong> (1.22 g, 5.0 mmol), Pd(PPh3)4 (0.30 g, 0.25 mmol, 5 mol %) and K2CO3 (1.56 g, 11.3 mmol) in degassed EtOH (25 mL) and PhMe (25 mL) under N2 was heated at reflux for 7 days, cooled, diluted with water (50 mL) and extracted with DCM (4*75 mL). The organic portions were dried with anhydrous sodium sulfate and the solvent removed in vacuo to yield a red oil. The residue was chromatographed on silica, eluting with 5% MeOH in ethyl acetate to yield 4,3':4',4"-terpyridine as a cream powder (0.66 g, 56.4%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 90℃; for 72h;Inert atmosphere; | Step (2),4-pyridylboronic acid pinacol ester (2.01 g, 9.8 mmol),Tetrakis(triphenylphosphine)palladium (407 mg, 0.352 mmol),Potassium phosphate (5.95 g, 28 mmol) was added to a 250 mL flask.Add 70 mL of Compound 4 (1.08 g, 3.61 mmol) in a nitrogen atmosphere.1,4-dioxane solution,The reaction solution is heated to 90 C,Reaction 72h,After the reaction is completed, cool to room temperature.filter,The filter residue is washed with chloroform.The filtrate was spun in a rotary evaporator.After that, it was purified by silica gel column chromatography (eluent was a mixture of chloroform:methanol=200:1).Purification gives a yellow solid, compound 5,Yield 60%; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | In 1,4-dioxane; N,N-dimethyl-formamide; at 130℃; for 72h; | General procedure: Compound 3b and 4b were synthesized according to the literature method. 5,5′-Dibromo-2,2′-bithiophene 1b (0.97g, 3.0mmol) and 4-pyridineboronic acid pinacol ester (2.0g, 10mmol) were dissolved in dried and degassed 1,4-dioxane/DMF (50mL, 1:1) and heated to 130C for 72h while stirring. The precipitate was isolated via vacuum filtration. The filtrate was concentrated under high vacuum to obtain the solid. After the solid was dissolved in CHCl3 and washed with H2O, concentrated hydrochloric acid (1-2mL) was added to the solution and the precipitate was collected and adjusted the pH to 8-9. The organic phases were dried over Na2SO4 and the solvent was evaporated to afford 3b as a yellow solid (0.70g, 73% yield) The data is consistent with the previously reported result [43]. The data is consistent with the previously reported results. |
Tags: 181219-01-2 synthesis path| 181219-01-2 SDS| 181219-01-2 COA| 181219-01-2 purity| 181219-01-2 application| 181219-01-2 NMR| 181219-01-2 COA| 181219-01-2 structure
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P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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