Structure of 179688-52-9
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CAS No. : | 179688-52-9 |
Formula : | C9H8N2O3 |
M.W : | 192.17 |
SMILES Code : | O=C1N=CNC2=C1C=C(O)C(OC)=C2 |
MDL No. : | MFCD07787563 |
Boiling Point : | No data available |
InChI Key : | OKZIRNNFVQCDSA-UHFFFAOYSA-N |
Pubchem ID : | 135446413 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Num. heavy atoms | 14 |
Num. arom. heavy atoms | 10 |
Fraction Csp3 | 0.11 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 4.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 50.88 |
TPSA ? Topological Polar Surface Area: Calculated from |
75.21 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.94 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.32 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
0.64 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.3 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.55 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
0.75 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.7 |
Solubility | 3.87 mg/ml ; 0.0202 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-1.46 |
Solubility | 6.62 mg/ml ; 0.0345 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.79 |
Solubility | 0.311 mg/ml ; 0.00162 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-7.25 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.68 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With pyridine; at 100℃; for 4h; | 6-hydroxy-7-methoxy-3H-quinazolin-4-one (1.92 g, 10 mmol) was added to acetic anhydride (20 mL)Pyridine (4 mL) was added with stirring,Heated at 100 C for 4 hours.After cooling to room temperature, add ice water quenching reaction,The precipitated white solid was the intermediate M-1 (2.32 g, 99%) |
96.6% | With pyridine; at 100℃; for 2h; | To the reaction vessel were added 6-hydroxy-7-methoxy-4 (3H) -quinazolinone (4.8 g, 25 mmol), 20 mL of acetic anhydride, pyridinehaeating upto 100 degree celcius for 2 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, the solvent was evaporated to dryness, and water was added to the residue to precipitate a solid. The resulting solid was washed with water, filtered and dried to give 6-ethoxycarbonyl-7-methoxy- Quinazolinone (2.26 g, yield 96.6% |
96% | With pyridine; In N,N-dimethyl-formamide; at 40 - 45℃; for 1h; | 100 g (0.52 mol) of the compound of the formula VI, 500 mL of N,N-dimethylformamide and 200 mL of pyridine were added to a 2 L three-necked flask, and 500 mL of acetic anhydride was added dropwise thereto, and the mixture was added dropwise, and the mixture was heated to 40-45 C for 1 hour. The end of the reaction was monitored by HPLC. The reaction solution was poured into 1.2 L of ice water, crystallized, filtered, and the solid was collected, and dried at 50 C to obtain a light brown compound I 117 g.The yield is 96% and the purity is 99%. |
93 - 96% | With pyridine; at 100℃; for 4h; | Step 5. A mixture of product step 4 (30.5 mmol), acetic anhydride (21.5 mL, 229 mmol) and pyridine (4.9 mL, 61 mmol) was heated to 100C for 4 h. After cooling to r.t., ice water (200 mL) was added and the mixture was vigorously stirred for 1 h. The precipitated 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (93-96%). |
93 - 96% | With pyridine; at 100℃; for 4h; | Step 5. A mixture of product step 4 (30.5 mmol), acetic anhydride (21.5 mL, 229 mmol) and pyridine (4.9 mL, 61 mmol) was heated to 100 C. for 4 h. After cooling to r.t., ice water (200 mL) was added and the mixture was vigorously stirred for 1 h. The precipitated 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (93-96%). |
82% | In pyridine; at 116℃; for 3h; | 6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one was obtained according to W096/33980 in 82% yield. The crude product was used for the next step without purification. |
75% | at 120 - 125℃; for 3h; | Into a reaction flask, acetic anhydride (864g, 16.25 m.eq) followed by 6-hydroxy- 7-methoxy-quinazoline-4(3H)-one of formula-XII (lOOg; 1.0 m.eq) were added under stirring and heated the reaction mass to 120-125C and maintained for about 3h. The progress of the reaction was monitored by TLC. After completion of reaction, cooled the reaction mass to 25-35C and quenched in ice water (2000g) under stirring. The resulting product mixture was heated to 60-65C, maintained for lh and cooled the reaction mass to 25-35C and maintained under stirring for 2h. The resulting product was isolated by filtration and washed with water. The product was further purified by recrystallization from dimethylformamide to afford 6-acetoxy-7-methoxy-quinazoline-4(3H)-one of formula-XV as crystalline solid (90.0g; 75% by theory). |
60% | With pyridine; dmap; at 100℃; for 4h; | The 6-hydroxy-7-methoxy -3H quinazolin-4-one (4g, 0.021mol), acetic anhydride (30 ml), pyridine (5 ml) and DMAP (10 mg) is added to the 50 ml reaction flask, stirring and heating to 100 C, reaction 4h, by adding ice water, filtered, ice water washing, to obtain white powdery solid, yield 60%. |
53% | With pyridine; at 20 - 100℃; for 3h; | To a suspension of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0.57 g) and pyridine (4 mL) was added acetic anhydride ( 10 mL) at room temperature. The reaction mixture was stirred at 100 C for 3 hours, and then poured into ice-water. The resulting mixture was filtered to give the title compound (0.40 g, 53.00 %). The compound was characterized by the following spectroscopic data: ? NMR (400 MHz, d6-DMSO) ?: 2.30 (s, 3H), 3.92 (s, 3H), 7.28 (s, 1 H), 7.75 (s, 1 H), 8.08 (s, 1 H). |
53% | With pyridine; at 100℃; for 3h; | To a suspension of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0.57 g) and pyridine (4 mL) was added acetic anhydride (10 mL) at room temperature. The reaction mixture was stirred at 100 C. for 3 hours, and then poured into ice-water. The resulting mixture was filtered to give the title compound (0.40 g, 53.00%). The compound was characterized by the following spectroscopic data: 1H NMR (400 MHz, d6-DMSO) δ: 2.30 (s, 3H), 3.92 (s, 3H), 7.28 (s, 1H), 7.75 (s, 1H), 8.08 (s, 1H). |
51% | With pyridine; at 100℃; for 6h; | Add 6-hydroxy-7-methoxy-3H-quinazolin-4-one (1 g, 5.2 mmol) in a 50 mL round bottom flask, acetic anhydride(20mL) and pyridine (4mL), the system was reacted at 100 C for 6h,The TLC detection of the starting material was complete.The reaction system was cooled to room temperature, and the round bottom flask was placed in an ice water bath and stirred.The suspension was then transferred to a 500 mL round bottom flask.In an ice water bath, add 300 mL of ice water and stir for 20 minutes.A large amount of white solid precipitated. Filter by suction, then wash the filter cake twice with water.Drying in an oven, the obtained white solid is (7-methoxy-4-oxo-3,4-dihydroquinazoline)-6-yl-acetate, yield51%. |
50% | With pyridine; for 3h;Heating / reflux; | A mixture of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0103) (1O g crude), acetic anhydride (100 ml) and pyridine (8ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to room temperature and poured into a mixture (250ml) of ice and water. The precipitate was isolated and dried to yield the title product 0104 as a grey solid (5.8g, 50% two step overall yield): LCMS: m/z 235[M+1]+; 1H NMR(CDCl31) δ 2.27 (s, 3H), 3.89 (s, 3H), 7.28 (s, IH), 7.72 (s, IH), 8.08 (d, IH), 12.20 (bs, IH). |
40% | With pyridine; dmap; at 100℃; for 6h;Inert atmosphere; | A suspension of compound 3 (3.88 g, 20.2 mmol), pyridine (4 mL) and DMAP (122 mg, 1.0 mmol) in acetic anhydride (30 mL) was heated to 100 C and stirred under N2 atmosphere for 6 h. The reaction mixture was cooled and poured into ice-water. The resultant precipitate was filtered, washed with water and dried under vacuum to afford 4 (1.88 g, 40%) as a beige solid, mp 303-305 C. 1H NMR (DMSO-d6): d 12.2 (s, 1H), 8.09 (s, 1H), 7.75 (s, 1H), 7.28 (s, 1H), 3.91 (s,3H), 2.30 (s, 3H). LC-MS (ESI, m/z): calcd for C11H11N2O4 ([M+H]+) 235.1, found 235.1. |
In pyridine; for 3h;Heating / reflux; | A mixture of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0103) (1O g crude), acetic anhydride (100 ml) and pyridine (8ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to room temperature and poured into a mixture (250ml) of ice and water. The precipitate was isolated and dried to yield the title product 0104 as a grey solid (5.8g, 50% two step overall yield): LCMS: m/z 235[M+1]+; 1H NMR(CDCU) δ 2.27 (s, 3H), 3.89 (s, 3H), 7.28 (s, IH), 7.72 (s, IH), 8.08 (d, IH), 12.20 (bs, IH). | |
With pyridine; for 3h;Heating / reflux; | Step 1c. 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate (Compound 0104) A mixture of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0103) (10 g crude), acetic anhydride (100 ml) and pyridine (8 ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to room temperature and poured into a mixture (250 ml) of ice and water. The precipitate was isolated and dried to yield the title product 0104 as a grey solid (5.8 g, 50% two step overall yield): LCMS: m/z 235 [M+1]+; 1H NMR (CDCl3.) δ 2.27 (s, 3H), 3.89 (s, 3H), 7.28 (s, 1H), 7.72 (s, 1H), 8.08 (d, 1H), 12.20 (bs, 1H). | |
With pyridine; at 20℃; | The compound of 15g GG3 placed 40ml of pyridine was added acetic anhydride (1.5 eq), stirred at room temperature overnight, the reaction was complete, poured into water, the precipitated solid was filtered to give compound GG4. | |
With pyridine; for 3h;Heating / reflux; | Step 1c. 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl Acetate (Compound 0104); A mixture of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (0103) (10 g crude), acetic anhydride (100 ml) and pyridine (8 ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to room temperature and poured into a mixture (250 ml) of ice and water. The precipitate was isolated and dried to yield the title product 0104 as a grey solid (5.8 g, 50% two step overall yield): LCMS: m/z 235[M+1]+; 1H NMR (CDCl3) δ 2.27 (s, 3H), 3.89 (s, 3H), 7.28 (s, 1H), 7.72 (s, 1H), 8.08 (d, 1H), 12.20 (bs, 1H). | |
6-Hydroxy-7-methoxy-4-ketoquinazoline (20 g, 0.11 mol, ie compound B1), acetic anhydride (150 mL, 1.6 mol) and pyridine (20 mL, 0.25 mol) were sequentially added to a 500 mL circle In the bottom flask, after heating to 100 C for 1 h, add 4-dimethylaminopyridine (0.9 g, 0.0073πο 1), continue the reaction for 5 h, stop the reaction, evaporate acetic anhydride under reduced pressure, and add cold to the reaction solution. The saturated sodium carbonate solution (500 mL) was stirred, suction filtered, and the filter cake was transferred to a round bottom flask and stirred with a large amount of ice water, suction filtered, and the filter cake was washed with distilled water until ΡΗ = 7, and dried to give a yellow-white solid ( Compound B2). This was sequentially added to a 500 mL three-neck round bottom flask with thionyl chloride (190 mL, 2.0 mol), and the mixture was heated to 80 C for reflux for 20 min, and N,N-dimethylformamide was slowly added from a constant pressure dropping funnel. (4.4 mL, 0.52 eq) was added dropwise to the reaction mixture. After reacting for 6 h, the reaction was stopped, cooled, and the thionyl chloride was recovered under reduced pressure. Toluene was added with stirring, and toluene was added under reduced pressure. Toluene (250 mL) was added to the reaction mixture and stirred for about 1 h, dichloromethane (120 mL*2) Extract and separate the organic layer,Wash with water (80 mL * 2), dry over anhydrous sodium sulfate, and dilute dichloromethane under reduced pressure.Obtained 21.5 g of an off-white solid, yield: 81.9%. | ||
117 g | With pyridine; In N,N-dimethyl-formamide; at 40 - 45℃; for 1h; | 100 g (0.52 mol) of the compound of the formula VI, 500 mL of N,N-dimethylformamide and 200 mL of pyridine were added to a 2 L three-necked flask, and 500 mL of acetic anhydride was added dropwise thereto, and the mixture was added dropwise, and the mixture was heated to 40-45 C for 1 hour. The end of the reaction was monitored by HPLC. The reaction solution was poured into 1.2 L of ice water, crystallized, filtered, and the solid was collected, and dried at 50 C to obtain a light brown compound I 117 g, a molar yield of 96%, a purity of 99%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With pyridine; acetic anhydride; | After repetition of the previous reaction, a mixture of 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one (14.18 g), acetic anhydride (110 ml) and pyridine (14 ml) was stirred and heated to 100 C. for 2 hours. The mixture was poured onto a mixture (200 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (13 g, 75%); NMR Spectrum: 2.3 (s, 3H), 3.8 (s, 3H), 7.3 (s, 1H), 7.8 (s, 1H), 8.1 (s, 1H), 12.2 (broad s, 1H). |
75% | With pyridine; acetic anhydride; | After repetition of the previous reaction, a mixture of 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one (14.18 g), acetic anhydride (110 ml) and pyridine (14 ml) was stirred and heated to 100 C. for 2 hours. The mixture was poured onto a mixture (200 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (13 g, 75%); NMR Spectrum: 2.3 (s, 3H), 3.8 (s, 3H), 7.3 (s, 1H), 7.8 (s, 1H), 8.1 (s, 1H), 12.2 (board s, 1H). |
75% | With pyridine; acetic anhydride; | After repetition of the previous reaction, a mixture of 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one (14.18 g), acetic anhydride (110 ml) and pyridine (14 ml) was stirred and heated to 100 C. for 2 hours. The mixture was poured onto a mixture (200 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (13 g, 75%); NMR Spectrum: 2.3 (s, 3H), 3.8 (s, 3H), 7.3 (s, 1H), 7.8 (s, 1H), 8.1 (s, 1H), 12.2 (broad s, 1H). |
46% | With pyridine; In water; acetic anhydride; | Step 2 7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate: Pyridine (3.95 g, 50.00 mmol, 2.00 equiv) was added to a solution of 6-hydroxy-7-methoxyquinazolin-4(3H)-one (4.8 g, 24.97 mmol, 1.00 equiv) in acetic anhydride (38 mL). The resulting solution was stirred at about 100 C. for about 4 hours, and then was poured into ice/water (200 ml). The resulting precipitate was isolated, washed with water, and dried in vacuo, to give the title product as a gray solid (2.7 g; yield=46%). |
6,7-dimethoxy-quinazolone was reacted with methanesulfonic acid and L-methionine under reflux for 2 h, and then the mixture was poured into ice water to deposit a solid, which is 6-hydroxy-7-methoxy-quinazolone intermediate. After the hydroxyl group therein was protected by acylation, the intermediate was treated with SOCl2 to obtain 4-chloro-6-acetoxy-7-methoxy-quinazoline. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With pyridine; at 100℃; for 3h; | (1-3) 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate; 6.08 g of the compound obtained in (1-2) was dissolved in a mixture of 550 mi of acetic acid and 7 mi of pyridine, and the resulting solution was stirred 100 C for 3 hours. The reaction solution was cooled to room temperature, and ice was added thereto to induce the crystallization of the product. The solid was filtered under a reduced pressure, washed with water, and air-dried to obtain the title compound (4.87 g, 65%). 1H-NMR (300MHz, DMSO-d6) δ 12.21 (s, IH), 8.09 (s, IH), 7.76 (s, IH),7.28 (s, IH), 3.91 (s, 3H), 2.30 (s, 3H). |
65% | With pyridine; at 100℃; for 3h; | 6.08 g of the compound obtained in (1-2) was dissolved in a mixture of 550ml of acetic acid and 7 ml of pyridine, and the resulting solution was stirred 1 00 00for 3 hours. The reaction solution was cooled to room temperature, and ice was added thereto to induce the crystallization of the product. The solid was filtered under a reduced pressure, washed with water, and air-dried to obtain the title compound (4.87 g, 65%).1H-NMR (300MHz, DMSO-d6) O 12.21 (s, 1H), 8.09 (s, 1H), 7.76 (s, 1H),7.28 (s, 1 H), 3.91 (s, 3H), 2.30 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; In N,N-dimethyl-formamide; at 80℃; for 3h; | Example 1: One kind of gefitinib preparation method, the steps of: three-necked flask 2.0gDMF, 30mL thionyl chloride and 2.9g of raw materials 1 (quinazolin-4-one, 20mmol), was heated to 80 reaction was stirred 3h.After the reaction, the solvent was distilled off under reduced pressure and the unreacted chlorinating agent, to the residue was added 20mL of toluene, concentrated under reduced pressure, was repeated three times.The resulting solid was dissolved in 250mLDMF, followed by adding 8.3gK2CO3, 6.2g side chain 3 (bromopropyl morpholino) side chains and 4.4g 4 (fluorochloroaniline), heated to 90 reaction was stirred 3h.After completion of the reaction, cooled to room temperature, stirring slowly added 1000mL of water, stirring was continued for 2h, after filtration and drying was 6g gefitinib crude.The crude product is recrystallized from ethyl acetate to give 5.8g white powder gefitinib |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20.5 g | With methanol; ammonia; water; for 6h;Reflux; | 28g 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-ol acetate(Compound 1), 32g of ammonia water (25% by mass), and 70g of methanol were added to the reaction flask, stirred for 6h under reflux conditions, TLC detected that the reaction was complete, filtered with suction, and then dried at 40C to obtain 20.5 g compound 2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With pyridine; at 80℃; for 1h; | The acetic anhydride (50 mL) mixture of 7-methoxyquinazoline-4, 6-diol (10.0 g, 52 mmol) and pyridine (8.2 g, 104 mmol) was heated to 80 C. for 1 h, and the reaction was completed by TLC detection.The reaction solution was cooled and distilled under reduced pressure. The residue was poured into 200 mL of water, filtered, and the filter cake was vacuum dried to obtain Intermediate 1 (12.1 g, yield 99%), which can be used in the next reaction without further purification. |
Tags: 179688-52-9 synthesis path| 179688-52-9 SDS| 179688-52-9 COA| 179688-52-9 purity| 179688-52-9 application| 179688-52-9 NMR| 179688-52-9 COA| 179688-52-9 structure
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Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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