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Chemical Structure| 177750-12-8 Chemical Structure| 177750-12-8

Structure of 177750-12-8

Chemical Structure| 177750-12-8

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Product Details of [ 177750-12-8 ]

CAS No. :177750-12-8
Formula : C10H10BrNO
M.W : 240.10
SMILES Code : CC(NC(C1=CC=C(Br)C=C1)=C)=O
MDL No. :MFCD20926112

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Application In Synthesis of [ 177750-12-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 177750-12-8 ]

[ 177750-12-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 177750-12-8 ]
  • [ 7500-37-0 ]
  • 2
  • [ 3240-34-4 ]
  • [ 177750-12-8 ]
  • [ 7500-37-0 ]
YieldReaction ConditionsOperation in experiment
95% In dichloromethane; water; at 50℃;Green chemistry; General procedure: A 10-mL round flask was charged with PhI(OAc)2 (0.24mmol, 77.3 mg) and enamides 1 (0.2 mmol, 1.0 equiv.) inCH2Cl2/H2O (2.0 mL, v/v=1:1). The flask was heated to50 C under vigorous stirring. Upon completion (detectedby thin layer chromatography (TLC)) of the reaction, thereaction mixture was cooled down to room temperature. Itwas quenched with H2O (5 mL) and extracted with EtOAc(2×10 mL). The combined organic layers were dried over anhydrousNa2SO4 and then evaporated in vacuo. The residuewas purified by column chromatography on silica gel withhexane/ethyl acetate (v/v=6:1) as the eluent to afford thecorresponding product 2.
 

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