Structure of 175358-01-7
*Storage:
*Shipping:
4.5
*For Research Use Only !
Change View
Size | Price | US Stock | Global Stock | In Stock |
100mg | łÇǶÊÊ | Inquiry | Inquiry | |
250mg | łÇͶÊÊ | Inquiry | Inquiry | |
1g | łËʶÊÊ | Inquiry | Inquiry | |
5g | łď˶ÊÊ | Inquiry | Inquiry | |
10g | łÇËî¶ÊÊ | Inquiry | Inquiry | |
25g | ł§Êÿ¶ÊÊ | Inquiry | Inquiry | |
100g | łÇÇÇʶÊÊ | Inquiry | Inquiry |
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
łÇǶÊÊ
łÇͶÊÊ
łËʶÊÊ
łď˶ÊÊ
łÇËî¶ÊÊ
ł§Êÿ¶ÊÊ
łÇÇÇʶÊÊ
In Stock
- +
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 175358-01-7 |
Formula : | C6H6ClN3O |
M.W : | 171.58 |
SMILES Code : | O=C(N)C1=NC(Cl)=CC=C1N |
MDL No. : | MFCD09750671 |
InChI Key : | ZGGQDDSXBIALBC-UHFFFAOYSA-N |
Pubchem ID : | 10749704 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Num. heavy atoms | 11 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 41.75 |
TPSA ? Topological Polar Surface Area: Calculated from | 82.0 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 0.34 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | -0.35 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 0.42 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | -0.39 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 0.45 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 0.09 |
Log S (ESOL):? ESOL: Topological method implemented from | -1.02 |
Solubility | 16.4 mg/ml ; 0.0953 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (Ali)? Ali: Topological method implemented from | -0.91 |
Solubility | 21.1 mg/ml ; 0.123 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -1.87 |
Solubility | 2.33 mg/ml ; 0.0136 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -7.6 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 1.73 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | at 140℃; for 2h; | Add 3 (2.5g, 14.6mmol) and triethyl orthoformate (100mL, 60mmol) in a 250mL eggplant-shaped bottle, react at 140 for 2h, complete reaction by TLC, cool to room temperature, filter to obtain filter cake, and dry to light yellow Solid 2.1g, yield 80%. |
72% | for 3h;Heating / reflux; | A suspension of e-chloro^-carboxamido-S-amino-pyridine (1.34 mmol, 230 mg) in triethyl orthoformate (10 ml) was refluxed for 3 hours. A white suspension was formed which was cooled down to room temperature. The precipitate was filtered off and dried under vacuum resulting in the pure title compound (174 mg, yield 72 %) which was characterised by its mass spectrum as follows: MS (m/z) : 182, 184([M+H]+, 100). |
42% | With acetic anhydride; for 2h;Reflux; | Acetic anhydride (15.1 mL, 160 mmol) was added to a mixture of 3-amino-6-chloro- pyridine-2-carboxamide (2.50 g, 14.6 mmol) and triethyl orthoformate (15.1 mL, 90.7 mmol). The reaction mixture was refluxed for 2 hours and it was cooled down to 20C which caused the formation of a precipitate. Isopropanol (20 mL) was added and the solid was filtered, washed with isopropanol and dried under vacuum to afford 6-chloropyrido[3,2-d]pyrimidin- 4(3H)-one (1.10 g, 6.06 mmol, 42% yield) as a beige solid. LCMS [M+H+] 182.0. |
at 145℃; for 3h; | a) Method for synthesising P-2a:; Cl theta-chloro^-cyano-S-nitropyridine (9.50 g, 51.76 mmol) is taken up in 150 ml. of 90 % H2SO4 solution. The reaction mixture is stirred for 4 h at 70 0C, cooled and slowly added dropwise to ice water. The precipitate formed is filtered off, washed with water and dried. The aqueous filtrate is extracted 6 x with DCM. The organic phases are combined, dried on Na2SO4, filtered off and concentrated by rotary evaporation. The residue is mixed with the precipitate, dried overnight at 50 0C in the drying cupboard and 6-chloro-3-nitro- pyridine-2-carboxylic acid amide (HPLC-MS: tRet = 0.43 min; MS (M+H)+ = 202) is obtained. theta-chloro-S-nitro-pyridine^-carboxylic acid amide (10.43 g, 51.75 mmol) is taken up in EtOH (250 ml_), combined with ammonium chloride (1.384 g, 25.87 mmol) in water(250 ml.) and heated to 60 0C. At this temperature iron powder (8.67 g, 155.23 mmol) is added batchwise and the mixture is stirred for 1 h at 60 0C. After cooling it is concentrated by rotary evaporation, filtered through silica gel, washed with DCM/MeOH (90/10 to 80/20), the resulting filtrate is evaporated down using the rotary evaporator and 3-amino- theta-chloro-pyridine^-carboxylic acid amide (HPLC-MS: tRet = 0.90 min; MS (M+H)+ = 172) is obtained.S-amino-theta-chloro-pyridine^-carboxylic acid amide (7.45 g, 43.41 mmol) is taken up in triethylorthoformate (150 mL) and stirred for 3 h at 145 0C. After cooling the precipitate formed is filtered off, washed with Et2O, dried and 6-chloro-3/-/-pyrido[3,2-d]pyrimidin-4- one (HPLC-MS: tRet = 0 min; MS (M+H)+ = 182) is obtained.6-chloro-3/-/-pyrido[3,2-d]pyrimidin-4-one (7.16 g, 39.43 mmol) and Lambda/,Lambda/-diethylaniline (9.505 mL, 59.14 mmol) are taken up in toluene (185 mL) and heated to 110 0C. Then POCI3 (3.713 mL, 39.43 mmol) is slowly added dropwise. The reaction mixture is stirred for a further 4 h at 110 0C. After cooling the mixture is diluted with toluene, washed 2 x with water, 2 x with 20 % NaOH solution and 1 x with 1 M HCI solution. The organic phase is dried on MgSO4, filtered off, evaporated down and P-2a is obtained (HPLC-MS: tRet = 1.14 min).Method of synthesis from: J. Med. Chem. 1996, 39, 1823-1835. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With iron; ammonium chloride; In ethanol; water; at 60℃; for 1.0h; | Pyridine Z.5 (2.00 g, 1 0.0 mmol) and iron filings (2.77 g, 49.6 mol) are taken up in EtOH/H20 (100 mL, 1 :1 ), combined with NH4CI (265 mg, 4.91 mmol) and heated to 60C for 1 h. The solvent is removed, the residue is taken up in DCM/MeOH (50 mL, 9:1 ), filtered through Celite, the solvent is eliminated again and pyridine Z.6 (1 .57 g, 92 %) is obtained. |
92% | With iron; ammonium chloride; In ethanol; water; at 60℃; for 1.0h; | Method of Synthesising the Azaquinazolines D*.2 and D.2Pyridine ED.4 (10.0 g, 54.5 mmol) is taken up in H2SO4 (150 mL, 90%) and heated to 70 C. for 3.5 h. Then the reaction mixture is cooled to 20 C., added dropwise to ice water, the precipitate is filtered off, washed with H2O, dried and pyridine Z.5 (10.5 g, 95%) is obtained.Pyridine Z.5 (2.00 g, 10.0 mmol) and iron filings (2.77 g, 49.6 mol) are taken up in EtOH/H2O (100 mL, 1:1), combined with NH4Cl (265 mg, 4.91 mmol) and heated to 60 C. for 1 h. The solvent is removed, the residue is taken up in DCM/MeOH (50 mL, 9:1), filtered through Celite, the solvent is eliminated again and pyridine Z.6 (1.57 g, 92%) is obtained.Pyridine Z.6 (500 mg, 2.91 mmol) is taken up in triethylorthoformate (10 mL) and heated to 145 C. for 18 h. Then the reaction mixture is cooled to 20 C., the precipitate is filtered off, washed with Et2O (10 mL), dried and azaquinazolone Z.7 (433 mg, 82%) is obtained.Azaquinazolone Z.7 (200 mg, 1.10 mmol) is placed in toluene (5.0 mL), combined with N,N-diethylaniline (0.27 mL) and POCl3 (0.88 mL) and heated to 110 C. for 4 h. The reaction mixture is cooled to 20 C., diluted with toluene (5 mL) and H2O (5 mL), washed with NaOH (3×10 mL, 20%) and HCl (2×10 mL, 1 M), dried on Na2SO4, filtered, freed from the solvent and azaquinazoline D*.2 (165 mg, 75%) is obtained.Azaquinazoline D*.2 (1.15 g, 5.75 mmol) is placed in DCM (5.0 mL), cooled to 0 C., combined with methylamine (3.5 mL, 7.19 mmol, 2 M in THF) and DIPEA (3.0 mL), the reaction mixture is heated to 20 C. and stirred for 1 h at 20 C. The solvent is removed, the residue is taken up in H2O, the precipitate is filtered off, washed with H2O and azaquinazoline D.2 (640 mg, 57%; HPLC-MS: MS (M+H)+=195; tRet.=1.85 min; method 1_BAS). |
89% | With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20℃; for 3.0h; | 6-Chloro-3-nitropicolinamide, 4.80 g (23.8 mmol), and palladium carbon (10%), 0.67 g (6.3 mmol), were added into 60 ml_ of ethyl acetate. The resulting mixture was stirred under hydrogen atmosphere (2 atm) for 3 hours at room temperature. Then palladium on carbon was filtered out and washed with ethyl acetate. The solvent was removed in vacuo to give 3.79 g (89%) of the product as a yellow solid. MS (ESIpos): m/z = 172 (M+H)+; LC-MS (Method 4, Acetonitrile-Water-0.1 % FA-10%B): Rt = 0.59 min. |
With iron; ammonium chloride; In ethanol; water; at 60℃; for 1.0h; | a) Method for synthesising P-2a:; Cl theta-chloro^-cyano-S-nitropyridine (9.50 g, 51.76 mmol) is taken up in 150 ml. of 90 % H2SO4 solution. The reaction mixture is stirred for 4 h at 70 0C, cooled and slowly added dropwise to ice water. The precipitate formed is filtered off, washed with water and dried. The aqueous filtrate is extracted 6 x with DCM. The organic phases are combined, dried on Na2SO4, filtered off and concentrated by rotary evaporation. The residue is mixed with the precipitate, dried overnight at 50 0C in the drying cupboard and 6-chloro-3-nitro- pyridine-2-carboxylic acid amide (HPLC-MS: tRet = 0.43 min; MS (M+H)+ = 202) is obtained. theta-chloro-S-nitro-pyridine^-carboxylic acid amide (10.43 g, 51.75 mmol) is taken up in EtOH (250 ml_), combined with ammonium chloride (1.384 g, 25.87 mmol) in water(250 ml.) and heated to 60 0C. At this temperature iron powder (8.67 g, 155.23 mmol) is added batchwise and the mixture is stirred for 1 h at 60 0C. After cooling it is concentrated by rotary evaporation, filtered through silica gel, washed with DCM/MeOH (90/10 to 80/20), the resulting filtrate is evaporated down using the rotary evaporator and 3-amino- theta-chloro-pyridine^-carboxylic acid amide (HPLC-MS: tRet = 0.90 min; MS (M+H)+ = 172) is obtained.S-amino-theta-chloro-pyridine^-carboxylic acid amide (7.45 g, 43.41 mmol) is taken up in triethylorthoformate (150 mL) and stirred for 3 h at 145 0C. After cooling the precipitate formed is filtered off, washed with Et2O, dried and 6-chloro-3/-/-pyrido[3,2-d]pyrimidin-4- one (HPLC-MS: tRet = 0 min; MS (M+H)+ = 182) is obtained.6-chloro-3/-/-pyrido[3,2-d]pyrimidin-4-one (7.16 g, 39.43 mmol) and Lambda/,Lambda/-diethylaniline (9.505 mL, 59.14 mmol) are taken up in toluene (185 mL) and heated to 110 0C. Then POCI3 (3.713 mL, 39.43 mmol) is slowly added dropwise. The reaction mixture is stirred for a further 4 h at 110 0C. After cooling the mixture is diluted with toluene, washed 2 x with water, 2 x with 20 % NaOH solution and 1 x with 1 M HCI solution. The organic phase is dried on MgSO4, filtered off, evaporated down and P-2a is obtained (HPLC-MS: tRet = 1.14 min).Method of synthesis from: J. Med. Chem. 1996, 39, 1823-1835. |
Tags: 175358-01-7 synthesis path| 175358-01-7 SDS| 175358-01-7 COA| 175358-01-7 purity| 175358-01-7 application| 175358-01-7 NMR| 175358-01-7 COA| 175358-01-7 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL