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Chemical Structure| 175136-30-8 Chemical Structure| 175136-30-8

Structure of 175136-30-8

Chemical Structure| 175136-30-8

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Product Details of [ 175136-30-8 ]

CAS No. :175136-30-8
Formula : C12H13NOS
M.W : 219.30
SMILES Code : CC1=C(CCO)N=C(C2=CC=CC=C2)S1
MDL No. :MFCD00218793

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Application In Synthesis of [ 175136-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 175136-30-8 ]

[ 175136-30-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10465-81-3 ]
  • [ 24985-85-1 ]
  • [ 175136-30-8 ]
  • [ 412007-74-0 ]
YieldReaction ConditionsOperation in experiment
With triphenylphosphine; In tetrahydrofuran; hexane; ethyl acetate; Example 220 Ethyl 5-[2-(5-methyl-2-phenyl-1,3-thiazol-4-yl)ethoxy]-1H-indole-2-carboxylate A solution of ethyl 5(hydroxy)-1H-indole-2-carboxylate (991 mg, 4.83 mmol) and 2-(5-methyl-2-phenyl-1,3-thiazol-4-yl)ethanol (1.06 g, 4.83 mmol) in tetrahydrofuran (30 +5 mL rinse) was added to a stirred mixture of triphenylphosphine (1.3 g, 4.9 mmol) and 1,1'-(azodicarbonyl)dipiperidine (1.2 g, 4.9 mmol) in tetrahydrofuran (10 mL). The reaction was stirred for 48 h and then diluted with ethyl acetate (200 mL). This solution was washed successively with water, 10% hydrochloric acid, and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo. Flash chromatography of the residue over silica gel using 25% ethyl acetate/hexane gave 1.04 g (53%) of the desired product. The product had: 1H NMR (300 MHz, acetone-D6) 10.40-10.55 (br s, 1 H), 7.89-7.95 (m, 2 H), 7.38-7.49 (m, 4 H), 7.19 (d, 1 H), 7.06-7.09 (m, 1 H), 6.95 (dd, 1 H), 4.30-4.40 (m, 4 H), 3.20 (t, 2 H), 2.51 (s, 3 H), 1.35 (t, 3 H); mass spectrometry gave MH+=407.1 (calc'd exact mass for C23H22N2O3S=406.14). The following compounds were prepared according to the method of Example 220:
 

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