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Structure of 17480-08-9

Chemical Structure| 17480-08-9

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Product Details of [ 17480-08-9 ]

CAS No. :17480-08-9
Formula : C9H12ClN
M.W : 169.65
SMILES Code : NC/C=C/C1=CC=CC=C1.[H]Cl
MDL No. :MFCD00184831
Boiling Point : No data available
InChI Key :RHJVYCBQGSIGEG-KQGICBIGSA-N
Pubchem ID :6444486

Safety of [ 17480-08-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 17480-08-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17480-08-9 ]

[ 17480-08-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 80-73-9 ]
  • [ 32618-85-2 ]
  • [ 17480-08-9 ]
  • [ 221043-17-0 ]
YieldReaction ConditionsOperation in experiment
13.0% With triethylamine; trichlorophosphate; In water; acetonitrile; Reference Example 4 2-Chloro-4-trans-cinnamylamino-6-nitroquinazoline To 400 mg (1.93 mmol) of 6-nitroquinazoline-2,4 (1H,3H)-dione were added 1 ml of 1,3-dimethyl-2-imidazolidinone and 2.96 g (19.3 mmol) of phosphorus oxychloride, and the resulting mixture was subjected to heating under reflux for 3 hours. After phosphorus oxychloride was removed in vacuo, the mixture was dissolved in 3 ml of acetonitrile, followed by addition of 5.94 ml (42.46 mmol) of triethylamine and 514 mg (3.86 mmol) of trans-cinnamylamine hydrochloride and stirring under ice cooling for 30 minutes. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 85 mg (yield: 13.0%) of the title compound. NMR (delta, CDCl3); 4.43-4.46 (2H, m), 6.35-6.42 (1H, m), 6.67 (1H, d, J=16 Hz), 7.24-7.42 (5H, m), 7.77 (1H, d, J=9 Hz), 8.45 (1H, dd, J=9 Hz, 2 Hz), 9.11 (1H, br), 9.44 (1H, d, J=2 Hz)
 

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