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Chemical Structure| 173999-05-8 Chemical Structure| 173999-05-8

Structure of 173999-05-8

Chemical Structure| 173999-05-8

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Product Details of [ 173999-05-8 ]

CAS No. :173999-05-8
Formula : C7H9BrN2O2S
M.W : 265.13
SMILES Code : CS(=O)(NCC1=CC(Br)=CN=C1)=O

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Application In Synthesis of [ 173999-05-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 173999-05-8 ]

[ 173999-05-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 352359-22-9 ]
  • [ 173999-05-8 ]
  • [ 1202552-15-5 ]
YieldReaction ConditionsOperation in experiment
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate;tris-(dibenzylideneacetone)dipalladium(0); In toluene; at 85℃; for 1.0h; A flask is charged with Λ/-(5-bromo-pyridin-3-ylmethyl)-methanesulfonamide (Example 163a, 530 mg, 2 mmol), Λ/-Boc-6-chloro-indole-2-boronic acid (525 mg, 3.0 mmol), s- Phos (41 mg, 0.10 mmol), finely crushed potassium phosphate (849 mg, 4.0 mmol) and toluene (20 ml_), and the mixture is degassed for 15 min. Pd2dba3 (37 mg, 0.04 mmol) is added and the mixture is stirred at 85 C for 1 h. The mixture is cooled to room temperature, diluted with DCM and silica gel (10 g) is added. The mixture is concentrated in vacuo and the residue is purified by silica gel flash chromatography eluting with a 0 to 90% ethyl acetate-heptane gradient to give 6-chloro-2-[5- (methanesulfonylamino-methyl)-pyridin-3-yl]-indole-1 -carboxylic acid tert-butyl ester. MS (ESI) m/z 436.1 and 437.9 (M+H)+.
 

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