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Chemical Structure| 17344-99-9 Chemical Structure| 17344-99-9

Structure of 17344-99-9

Chemical Structure| 17344-99-9

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Product Details of [ 17344-99-9 ]

CAS No. :17344-99-9
Formula : C5H11NO2
M.W : 117.15
SMILES Code : CC(N)C(OCC)=O
MDL No. :MFCD00192672

Safety of [ 17344-99-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 17344-99-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17344-99-9 ]

[ 17344-99-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 17344-99-9 ]
  • [ 349-43-9 ]
  • [ 10117-10-9 ]
  • 2
  • [ 17344-99-9 ]
  • [ 19064-24-5 ]
  • ethyl 2-(3-fluoro-2-nitrophenylamino)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 110℃; for 16h; Example 20a; ethyl 2-(3-fluoro-2- nitrophenylamino)propanoate; To a solution of l,3-difluoro-2-nitrobenzene (4.7 g, 29.5 mmol) in DMA (98 ml) was added ethyl 2-aminopropanoate (3.46 g, 29.5 mmol) and diisopropylethylamine (25.8 ml, 148 mmol). The reaction was heated at 110 C 16 h, cooled to rt, diluted with 2N HC1 and extracted with isopropyl acetate two times. The organic layers were combined and washed with water 3 times and brine once, dried (anh. Na2S04) and concentrated. The residue was purified by chromatography on silica gel (100 g) eluting ethyl acetate in hexane in a gradient of 0-30% to give the title compound 20a (5.8 g, 77% yield)
 

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