[ CAS No. 173340-26-6 ] {[proInfo.proName]}

Name: 173340-26-6|(S)-tert-Butyl (pyrrolidin-3-ylmethyl)carbamate|97%
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Product Details of [ 173340-26-6 ]

CAS No. :	173340-26-6	MDL No. :	MFCD06796616
Formula :	C₁₀H₂₀N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WIEJVMZWPIUWHO-QMMMGPOBSA-N
M.W :	200.28	Pubchem ID :	1519426
Synonyms :

Safety of [ 173340-26-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 173340-26-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 173340-26-6 ]
Downstream synthetic route of [ 173340-26-6 ]

[ 173340-26-6 ] Synthesis Path-Upstream 1~1

1
[ 173340-24-4 ]
[ 173340-26-6 ]

Yield	Reaction Conditions	Operation in experiment
76%	With hydrogen In methanol for 24 h;	[l-(l-Phenyl-ethyl)-pyrrolidin-3-ylmethyl]-carbamic acid tert-butyl ester (3.50g, 11.5 mmol) was taken up in methanol and charged with 20percentPd/C then subjected to 50 psi hydrogenation conditions. After 24 hours the reaction was filtered and concentrated leaving 1.75g of title compound (yield: 76percent). MS (APCI+):7n/z 201 (M+H) +.
76%	With hydrogen In methanol for 24 h;	[1- (l-Phenyl-ethyl)-pyrrolidin-3-ylmethyl]-carbamic acid tert-butyl ester (3. 50g, 11.5 mmol) was taken up in methanol and charged with20percent Pd/C then subjected to 50 psi hydrogenation conditions. After 24 hours the reaction was filtered and concentrated leaving 1.75g of title compound (yield: 76percent). MS (APCI+):m/z 201 (M+H) +.

Reference： [1] Patent: WO2005/49602, 2005, A1, . Location in patent: Page/Page column 88; 89; 124
[2] Patent: WO2005/49605, 2005, A1, . Location in patent: Page/Page column 116; 117; 152

[ 173340-26-6 ] Synthesis Path-Downstream 1~21

1
[ 173340-24-4 ]
[ 173340-26-6 ]

Yield	Reaction Conditions	Operation in experiment
76%	With hydrogen;palladium on carbon; In methanol; under 2585.81 Torr; for 24h;	[l-(l-Phenyl-ethyl)-pyrrolidin-3-ylmethyl]-carbamic acid tert-butyl ester (3.50g, 11.5 mmol) was taken up in methanol and charged with 20%Pd/C then subjected to 50 psi hydrogenation conditions. After 24 hours the reaction was filtered and concentrated leaving 1.75g of title compound (yield: 76%). MS (APCI+):7n/z 201 (M+H) +.
76%	With hydrogen;palladium on carbon; In methanol; under 2585.81 Torr; for 24h;	[1- (l-Phenyl-ethyl)-pyrrolidin-3-ylmethyl]-carbamic acid tert-butyl ester (3. 50g, 11.5 mmol) was taken up in methanol and charged with20% Pd/C then subjected to 50 psi hydrogenation conditions. After 24 hours the reaction was filtered and concentrated leaving 1.75g of title compound (yield: 76%). MS (APCI+):m/z 201 (M+H) +.

Reference： [1]Patent: WO2005/49602,2005,A1 .Location in patent: Page/Page column 88; 89; 124
[2]Patent: WO2005/49605,2005,A1 .Location in patent: Page/Page column 116; 117; 152

2
[ 173340-26-6 ]
[ 944704-43-2 ]
[ 1016167-78-4 ]

Reference： [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 1730 - 1739

3
[ 173340-26-6 ]
[ 93913-86-1 ]
C₂₁H₃₂N₄O₃ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 5952 - 5958

4
[ 173340-26-6 ]
[ 1257832-31-7 ]
[ 1257832-42-0 ]

Yield	Reaction Conditions	Operation in experiment
45%	With sodium t-butanolate;4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0); In toluene; at 100℃;microwave irradiation; Inert atmosphere;	Example 19; N-{(S)-3-[6-tert-Butyl-8-(dioxo-tetrahydro-pyrimidin-1-yl)-5-methoxy-quinolin-3-yl]-cyclopentyl}-methanesulfonamide (I-31); step 1-; A dried microwave tube was purged with argon and charged with 86 (0.47 g, 1.26 mmol), (S)-1-pyrrolidin-3-ylmethyl-carbamic acid tent-butyl ester (0.38 g, 1.897 mmol, CASRN 173340-26-6), sodium tert-butoxide (0.18 g, 1.873 mmol), xantphos (0.146 g, 0.252 mmol), and Pd2(dba)3(0) (0.115 g, 0.126 mmol). The tube was purged with argon, and 1 mL of toluene was added. The reaction mixture was degassed for 15 min by bubbling argon through the mixture and the resulting mixture was stirred at 100 C. overnight, cooled to RT and partitioned between EtOAc and sat'd. aq. NH4Cl. The aqueous layer was back extracted twice with EtOAc. The combined organic extracts were dried (Na2SO4), filtered, and evaporated. The residue was purified by SiO2 chromatography (40 g SiO2) eluting with an EtOAc/hexane gradient (10 to 30% EtOAc), to afford 0.28 g (45%) of 90a.

Reference： [1]Patent: US2010/311760,2010,A1 .Location in patent: Page/Page column 43-44

5
[ 173340-26-6 ]
[ 1314605-44-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 3627 - 3631

6
[ 173340-26-6 ]
C₂₆H₃₂N₄O [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 3627 - 3631

7
[ 173340-26-6 ]
[ 1301177-27-4 ]
C₃₁H₄₁BrN₄O₃ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 3627 - 3631

8
[ 173340-26-6 ]
(S)-N-(4-chloro-2-(2-(5-chloro-6-methylpyrazolo[1,5-a]-pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide [ No CAS ]
C₃₀H₄₀ClN₇O₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In methanol; at 70℃; for 12h;	Example 138 Preparation of Compound 21 [0932] [0933] To a solution of intermediate 11 (30.0 mg, 62.0 mumol) in MeOH (1 mL) was added (S)-tert-butyl-pyrrolidin-3-ylmethylcarbamate (146 mg, 0.62 mmol) and triethylamine (174 muL, 1.25 mmol) at room temperature, and the reaction mixture was heated to 70 C. After 12 h, the reaction mixture was allowed to cool to room temperature and was purified by preparatory HPLC (5-100% MeCN/H2O, 0.1% trifluoroacetic acid modifier). Trifluoroacetic acid (1 mL) was added at room temperature. After 30 min, the resulting mixture was concentrated to afford compound 21 (40.0 mg, 98%) as a light yellow solid trifluoroacetate salt. [0934] LCMS (ESI) m/z 546.19 [M+H]+, tR=1.95 min. [0935] MW 545.20

Reference： [1]Patent: US2013/273037,2013,A1 .Location in patent: Paragraph 0932-0935

9
[ 173340-26-6 ]
[ 1485748-96-6 ]
[ 1485748-98-8 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 1914 - 1931

10
[ 173340-26-6 ]
[ 1257832-13-5 ]
[ 1485748-96-6 ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 1914 - 1931

11
[ 173340-26-6 ]
7-bromo-5-cyclopropyl-6-methyl-oxazolo[4,5-c]quinolin-4-one [ No CAS ]
tert-butyl N-[(3R)-1-{7-bromo-5-cyclopropyl-6-methyl-4-oxo-oxazolo[4,5-c]quinolin-2-yl}pyrrolidin-3-yl]methyl}carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37.5%	With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; acetic acid; In acetonitrile; at 80℃; for 2h;Microwave irradiation;	(S)-3-N-Boc-aminomethylpyrrolidine (86.6 mg, 0.43 mmol) was placed in a 0.5 - 2 mL microwave vial and tetrabutylammonium iodide (3.99 mg, 0.01 mmol) and 7-bromo-5- cyclopropyl-6-methyl-oxazolo[4,5-c]quinolin-4-one (69 mg, 0.22 mmol) (prepared from W02015155549 Example I steps (a)-(f)) added as solids. ACN (0.70 mL) was added followed by glacial CH3000H (0.04 mL, 0.65 mmol) then TBHP (0.04 mL, 0.32 mmol). The reaction was heated to 80C for 2 h in the microwave. On cooling DCM (30 mL) was added to the crude reaction mixture followed by 2M sodium disulfite (10 mL). The organic was washed with sat. aq. NaHCO3 (5 mL) then dried (Na2SO4), filtered and evaporated under reduced pressure to leave the crude product. This was purified by flash silica chromatography using 0-100% EtOAc in DCM as eluent. The solvent was removed from fractions containing the product to give teit-butyl N-[[(3R)-1-(7-bromo-5-cyclopropyl-6- methyl-4-oxo-oxazolo[4, 5-c]qui nol in-2-yl)pyrrolidin-3-yl]methyl]carbamate (42 mg, 37.5 % yield) as a brown solid.

Reference： [1]Patent: WO2017/46606,2017,A1 .Location in patent: Page/Page column 170

12
[ 173340-26-6 ]
4-chloro-3-cyclobutyl-1-phenylpyrazolo[3,4-b]pyridine-6-carboxylic acid [ No CAS ]
4-[(3R)-3-[(tert-butoxycarbonyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
298 mg		A suspension of intermediate HP02 (230 mg, 0.70 mmol), (S)-tert-butyl(pyrrolidin-3-ylmethyl)carbamate (200 mg, 1.0 mmol) and triethylamine (245 muL, 1.76 mmol) in anhydrous DMA (600 muL) was heated in a Biotage Initiator microwave synthesizer at 150 C. for fifteen minutes. DBU (125 muL, 0.84 mmol) was added, and the reaction mixture was heated at 150 C. with microwave irradiation for one hour, brought to room temperature, treated with acetic acid (200 muL) and chromatographed on silica (100nM MeCN then 0.2nM HOAc in 1:9 MeOH/MeCN). The appropriate fractions were concentrated, and the residue was swirled with water/methanol until a precipitate formed. The solid was collected by filtration, rinsed with methanol/water and dried under vacuum to give the titled compound (292 mg).

Reference： [1]Patent: US2017/101406,2017,A1 .Location in patent: Paragraph 1975; 1976; 1977; 1998; 1999

13
[ 173340-26-6 ]
4-chloro-3-cyclobutyl-1-phenylpyrazolo[3,4-b]pyridine-6-carboxylic acid [ No CAS ]
4-[(3S)-3-[(tert-butoxycarbonyl)(methyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid [ No CAS ]

Reference： [1]Patent: US2017/101406,2017,A1

14
[ 173340-26-6 ]
4-[4-(6-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-[1,2,3]triazol-1-yl]benzoic acid [ No CAS ]
C₂₈H₂₉FN₆O₄ [ No CAS ]

Reference： [1]Patent: WO2017/121444,2017,A1 .Location in patent: Page/Page column 229

15
[ 173340-26-6 ]
(R)-N-chloro-1-(pyrrolidin-3-yl)methanamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20℃; for 12h;	To a stirred solution of compound tert-butyl (pyrrolidin-3-ylmethyl)carbamate (0.2g, 0.99 mmol, 1 eqiuv) in dichloro methane (10 mL) at 0C,was added 4M HCI indioxane(1 0 mL) drop wise manner. After stirring for 5 minutes at 0C reaction mixture was allowed to stirred at room temperature for 12 hours. Solvent was evaporated from reaction mixture; obtained solid was washed with di ethyl ether (10 mL). Solid was filtered and dried to get (R)-N-chloro-1-(pyrrolidin-3-yl)methanamine compound with dihydrogen (1:2) hydrochloride (0.17 g, crude) taken for next step.1H NMR (400 MHz, DMSO-d6): O1.63-1.72 (m, 1 H), 2.01 -2.10 (m, 1 H), 2.48-2.58 (m, 1 H), 2.86-2.95 (m, 3 H),3.09-3.12 (m, 1 H), 3.19 Cbs, 1 H), 3.27-3.29 (m, 1 H), 8.21 (bs, 3 H), 9.39-9.46 (m,2 H).

Reference： [1]Patent: WO2017/212423,2017,A1 .Location in patent: Page/Page column 85; 86

16
[ 173340-26-6 ]
(S)-2-(4-chlorophenoxy)-N-((1-(2-(4-chlorophenoxy)acetyl)pyrrolidin-3-yl)methyl)acetamide [ No CAS ]

Reference： [1]Patent: WO2017/212423,2017,A1

17
[ 173340-26-6 ]
4-(6-fluoropyridin-3-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazine-3-carbonitrile [ No CAS ]
tert-butyl (R)-((1-(5-(3-cyano-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)pyridin-2-yl)pyrrolidin-3-yl)methyl)carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	With potassium carbonate; In dimethyl sulfoxide; at 110℃; for 72h;	A solution of 4- (6-fluoropyridin-3-yl)-6-(l-methyl-lH-pyrazol-4-yl)pyrazolo[l,5-a]pyrazine-3-carbonitrile (2522) (Intermediate P7; 0.1019 g, 0.3191 mmol) in DMSO (6.4 mL) was treated with tert-butyl (S)- (pyrrolidin-3-ylmethyl)carbamate (0.2557 g, 1.277 mmol) and K2CO30 (0.1767 g, 1.277 mmol) and stirred 3 d at 110 C. After cooling to ambient temperature, the reaction mixture was diluted with water (10 mL), and extracted with DCM (2 x 20 mL). The combined organic extracts were dried over anhydrous MgS04(S), filtered, and concentrated in vacuo. The residue was purified by silica chromatography (using 0-100% EtOAc/Hexanes as the gradient eluent). Fractions containing the desired product were concentrated in vacuo, then suspended in water (to remove residual DMSO), filtered and dried in vacuo to afford the title compound (67 mg, 42% yield). MS (apci) m/z = 500.2 (M+H).

Reference： [1]Patent: WO2018/136661,2018,A1 .Location in patent: Paragraph 001267

18
[ 173340-26-6 ]
(R)-4-bromo-2-fluoro-N-(1-(3-propoxyphenyl)ethyl)benzamide [ No CAS ]
tert-butyl (((R)-1-(5-bromo-2-(((R)-1-(3-propoxyphenyl)ethyl)carbamoyl)phenyl)pyrrolidin-3-yl)methyl)carbamate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 11074 - 11100

19
[ 173340-26-6 ]
1-([1,1'-biphenyl]-4-ylmethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid [ No CAS ]
(S)-1-([1,1'-biphenyl]-4-ylmethyl)-7-(3-(aminomethyl)pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%		UICK-III-197 (1.5 g, 3.8 mmol) was dissolved in 40mL ACN towhich was added Boc-(R)-aminomethylpyrrolidine (921.1 mg,4.600 mmol) and DIPEA (1 mL, 5.7 mmol). The reaction was set tostir at 70 C for 4 h. 25mL 4 N HCl was then added and the reactionwas stirred for additional 12 h. The resultant precipitate wasfiltered and washed with ACN to give pure UICK-II-065 (5a) (BatchCK-III-199). Yield 1.5 g, 77%. 1H NMR (300 MHz, DMSO) d 15.61 (s,1H, exchangeable), 9.19 (s, 1H), 8.16 (bs, 2H), 7.80 (d, J 14.3 Hz,1H), 7.66 (dd, J 12.5, 7.9 Hz, 4H), 7.42 (m, 5H), 6.67 (d, J 7.5 Hz,1H), 5.83 (s, 2H), 3.68 (m, 1H), 3.48 (m, 3H), 2.90 (m, 2H), 2.55 (m,1H), 2.11 (m,1H),1.79 (m,1H). 19F NMR (282 MHz, DMSO) d 126.75(s, 1F). MS ESI calculated for (M H) 472.20, found 472.20.Retention time (analytical HPLC) 19.0 min.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 172,p. 109 - 130

20
[ 173340-26-6 ]
1-([1,1'-biphenyl]-4-ylmethyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid [ No CAS ]
(R)-1-([1,1'-biphenyl]-4-ylmethyl)-6-fluoro-4-oxo-7-((pyrrolidin-3-ylmethyl)amino)-1,4-dihydroquinoline-3-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%		UICK-III-197 (26) (100 mg, 0.26 mmol) was dissolved in 2mLDMSO to which was added (S)-3-(Aminomethyl)-1-N-Boc-pyrrolidine(76.9 mg, 0.38 mmol) and DIPEA (89 mL, 0.51 mmol). The reactionwasset to stir at 40 C for 1.5 h. To the reaction mixture 1 mLof 6 N HCl was added and stirred for 18 h. To the reaction mixturewaterwas added and the resulting mixturewas centrifuged and thesupernatant removed. The remaining precipitant was washed withwater and centrifuged again. The resulting precipitate was lyophilizedand pure UICK-IV-093 (5i)was isolated, 95.5 mg, 68%. 1H NMR(300 MHz, DMSO) d 9.15 (s, 1H), 9.03 (bs, 1H, exchangeable), 7.82 (d,J 11.9 Hz, 1H), 7.67 (m, 4H), 7.42 (m, 5H), 7.22 (bs, 1H, exchangeable),6.81 (d, J 7.1 Hz, 1H), 5.88 (s, 2H), 3.29 (m, 2H), 3.16 (m, 2H),2.92 (m, 2H), 2.36 (m, 1H), 1.87 (m, 1H), 1.57 (m, 1H). 19F NMR(282 MHz, DMSO) d 132.24 (s, 1F). MS ESI calculated for (M H)472.20, found 472.20. Retention time (analytical HPLC) 19.1 min.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 172,p. 109 - 130

21
[ 173340-26-6 ]
[ 98-74-8 ]
C₁₆H₂₃N₃O₆S [ No CAS ]

Reference： [1]Patent: WO2019/204505,2019,A2 .Location in patent: Paragraph 0378

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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 173340-26-6 ] {[proInfo.proName]}

Quality Control of [ 173340-26-6 ]

Related Doc. of [ 173340-26-6 ]

Product Details of [ 173340-26-6 ]

Safety of [ 173340-26-6 ]

Application In Synthesis of [ 173340-26-6 ]

[ 173340-26-6 ] Synthesis Path-Upstream 1~1

[ 173340-26-6 ] Synthesis Path-Downstream 1~21

Related Functional Groups of [ 173340-26-6 ]

Amides

Amines

Related Parent Nucleus of [ 173340-26-6 ]

Pyrrolidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 173340-26-6 ]

Related Parent Nucleus of
[ 173340-26-6 ]