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Chemical Structure| 172739-04-7 Chemical Structure| 172739-04-7

Structure of 172739-04-7

Chemical Structure| 172739-04-7

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Product Details of [ 172739-04-7 ]

CAS No. :172739-04-7
Formula : C13H18N2
M.W : 202.30
SMILES Code : [H][C@]12CN(CC3=CC=CC=C3)C[C@@]1([H])CNC2
MDL No. :MFCD04116222

Safety of [ 172739-04-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H335-H314
Precautionary Statements:P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 172739-04-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 172739-04-7 ]

[ 172739-04-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 172739-04-7 ]
  • [ 135865-78-0 ]
  • [ 872001-34-8 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20℃; for 4h; EXAMPLE 3; 2-Cyclohexyl-N-{(S)-3-[5-(2,6-dimethyl-benzoyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-malonamic acid methyl ester (I-20) and 2-cyclohexyl-N-{(S)-3-[5-(2,6-dimethyl-benzoyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl-1-phenyl-propyl}-malonamic acid; trifluoroacetate salt (I-14); Step 1-; A mixture of 43 (4.07 g, 16.3 mmol), 11a (3.0 g, 14.8 mmol), NaBH(OAc)3 (4.71 g, 22.2 mmol) and HOAc (2.1 mL, 37.1 mmol) in DCM (100 mL) was stirred at RT for 4 h. The reaction was quenched by addition of 5percent NaHCO3. The organic layer was separated and the aqueous layer was extracted with DCM. The combined organic extracts were dried (MgSO2), filtered and concentrated in vacuo. The residue was purified via SiO2 chromatography eluting with DCM/MeOH to afford 44a.
 

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