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Chemical Structure| 17137-11-0 Chemical Structure| 17137-11-0

Structure of 17137-11-0

Chemical Structure| 17137-11-0

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Product Details of [ 17137-11-0 ]

CAS No. :17137-11-0
Formula : C11H8ClNO3
M.W : 237.64
SMILES Code : O=C(Cl)CCN(C(C1=C2C=CC=C1)=O)C2=O
MDL No. :MFCD00023095
InChI Key :ZEQHPUCQCWTFRP-UHFFFAOYSA-N
Pubchem ID :86966

Safety of [ 17137-11-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H317
Precautionary Statements:P280-P301+P310
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 17137-11-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17137-11-0 ]

[ 17137-11-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2346-00-1 ]
  • [ 17137-11-0 ]
  • [ 121-44-8 ]
  • [ 71-43-2 ]
  • [ 100969-99-1 ]
  • 2
  • [ 17137-11-0 ]
  • [ 20605-41-8 ]
  • 3-(1,3-dioxoisoindolin-2-yl)-N'-(2-methoxyacetyl)propanehydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 0 - 20℃; for 1h; Step-1: 3-(1,3-dioxoisoindolin-2-yl)-N'-(2-methoxyacetyl)propanehydrazide Oxalyl chloride (27.47 g, 0.216 mol) was added slowly to an ice-cooled solution of 3-(1,3-dioxoisoindolin-2-yl)propanoic acid (15.80 g, 0.072 mol) in DCM (250 mL) followed by catalytic DMF (0.5 mL). The reaction mixture was stirred at room temperature for 1 h and volatiles were removed completely under vacuum to obtain the intermediate acid chloride as a yellow solid. A solution of <strong>[20605-41-8]2-<strong>[20605-41-8]methoxyacetohydrazide</strong></strong> (2, 9.01 g, 0.086 mol) in DCM (50 mL) was added to a solution of this acid chloride in DCM (200 mL) at 0° C. followed by triethylamine (60.5 g, 0.597 mol). The resultant reaction mixture was stirred at room temperature for 1 h. The resulting yellow suspension was quenched onto crushed ice (200 mL). Separated organic layer was washed with water (2×200 mL), brine (150 mL) and concentrated under vacuum to afford crude product (5 g). The aqueous layer which also contains desired product was concentrated under reduced pressure to afford a solid residue. The crude residue was dried and extracted sequentially with THF (1000 mL), acetone (300 mL) and acetonitrile (400 mL). The combined organic layer was concentrated to obtain yellow semisolid (37 g) which was combined with solid residue (5 g) from organic layer and was used in the next reaction without purification. LC-MS [M+H]+ 306.1 m/z.
 

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