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Chemical Structure| 171258-08-5 Chemical Structure| 171258-08-5

Structure of 171258-08-5

Chemical Structure| 171258-08-5

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Product Details of [ 171258-08-5 ]

CAS No. :171258-08-5
Formula : C16H12O
M.W : 220.27
SMILES Code : CC(C1=CC=CC=C1C#CC2=CC=CC=C2)=O
MDL No. :MFCD29761068

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Application In Synthesis of [ 171258-08-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 171258-08-5 ]

[ 171258-08-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 32024-15-0 ]
  • [ 171258-08-5 ]
  • [ 1338235-56-5 ]
  • 2
  • [ 443-86-7 ]
  • [ 171258-08-5 ]
  • N-(3-fluoro-2-methylphenyl)-3-phenylnaphthalen-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With copper(ll) sulfate pentahydrate; In 1,2-dichloro-ethane; at 100℃; for 14h;Inert atmosphere; General procedure: A mixture of 2-(phenylethynyl)acetophenone (1a, 110 mg, 0.5 mmol), 4-methyl-aniline (2b, 75 mg, 0.7 mmol), CuSO4·5H2O (7 mg, 0.025 mmol, 5 molpercent) and DCE (2.0 mL) was heated at 100 °C (oil bath temperature) with stirring in a 25 mL screw-capped thick-walled Pyrex tube under nitrogen atmosphere. When TLC control showed the completion of the reaction (after 14 h), the reaction mixture was quenched with H2O. The mixture was extracted with dichloromethane (DCM) three times, and dried over Na2SO4. The solvent was evaporated and the crude residue was purified by column chromatography on silica gel to afford 3ab as a white solid in 83percent yield (128 mg).
 

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