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Chemical Structure| 16874-06-9 Chemical Structure| 16874-06-9
Chemical Structure| 16874-06-9

H-Glu(OtBu)-OtBu

CAS No.: 16874-06-9

Synonyms: H-Glu(OtBu)-OtBu

4.5 *For Research Use Only !

Cat. No.: A236126 Purity: 97%

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Product Details of H-Glu(OtBu)-OtBu

CAS No. :16874-06-9
Formula : C13H25NO4
M.W : 259.34
SMILES Code : N[C@@H](CCC(OC(C)(C)C)=O)C(OC(C)(C)C)=O
Synonyms :
H-Glu(OtBu)-OtBu
MDL No. :MFCD00038271
InChI Key :NTUGPDFKMVHCCJ-VIFPVBQESA-N
Pubchem ID :208637

Safety of H-Glu(OtBu)-OtBu

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of H-Glu(OtBu)-OtBu

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16874-06-9 ]

[ 16874-06-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 16874-06-9 ]
  • [ 17823-69-7 ]
  • [ 118534-51-3 ]
  • 2
  • [ 16874-06-9 ]
  • [ 47375-34-8 ]
  • Boc-Tyr(OtBu)-Glu(OtBu)-OtBu [ No CAS ]
YieldReaction ConditionsOperation in experiment
Boc-Tyr(tBu)-OH (1.31 g, 3.87 mmol, 1.2 eqv) was dissolved in 20 ml DCM. DIPEA (3.37 ml, 19.34 mmol, 6 eqv) was added. The reaction mixture was stirred at room temperature for 1 hour. H-Glu(OtBu)-OtBu (0.95 g, 3.22 mmol, 1 eqv), HOBt (0.48 g, 3.55mmol, 1.1 eqv) and EDCI x HCI(0.68 g, 3.55 mmol, 1.1 eqv) were added and the reaction mixture was stirred for 24 hours. The RM was diluted to 150 ml with DCM and the organic layer was washed with 3x 100 ml 0.1M HCI, lx 150 ml brine, 3x 100 ml NaHCO 3(sat) and 2x 150 ml brine, dried over Mg504, filtered and concentrated in vacuo. <strong>[47375-34-8]Boc-Tyr(OtBu)</strong>-Glu(OtBu)-OtBu was (1.64 g, 87.8 %) was obtained as crude whitefoam and used without further purification. 1HNMR (400MHz, CDCI3) ö 7.09 (d, J = 8.5 Hz, 2H, Ar-H), 6.91 (d, J= 8.5 Hz, 2H, Ar-H), 6.55 (d, J = 7.5 Hz, 1H, NH), 4.43 (td, J = 4.5, 1 H, CH-xglutamicacid), 4.32 (s, 1 H, CHcftyrosine), 3.02(d, J = 6.5 Hz, 2H, CH2-B tyrosine),2.16 (m, 2H, OH2- glutamic acid and CH211 glutamicacid), 1.85 (m, 1H, CH2-B glutamicacid), 1.61 (br5, 2H, CH2-glutamicacid), 1.44 (s, 18H, C(CH3)3), 1.41 (s, 9H, C(CH3)3), 1.32 (s, 9H,C(CH3)3).
 

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