Structure of 16657-07-1
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CAS No. : | 16657-07-1 |
Formula : | C9H7Br |
M.W : | 195.06 |
SMILES Code : | BrC1=CC=CC2=C1CC=C2 |
MDL No. : | MFCD16652275 |
InChI Key : | JTRQKQGKIYROIO-UHFFFAOYSA-N |
Pubchem ID : | 13330209 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 10 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.11 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 0.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 47.08 |
TPSA ? Topological Polar Surface Area: Calculated from | 0.0 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 2.36 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 3.4 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 2.91 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 3.5 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 3.4 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 3.11 |
Log S (ESOL):? ESOL: Topological method implemented from | -3.64 |
Solubility | 0.0452 mg/ml ; 0.000232 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (Ali)? Ali: Topological method implemented from | -3.08 |
Solubility | 0.162 mg/ml ; 0.000833 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -3.62 |
Solubility | 0.0473 mg/ml ; 0.000243 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -5.08 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.54 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | With ammonium chloride; In tetrahydrofuran; water; | (1) Synthesis of 7-isopropylindene Using a 300 ml three-necked flask as the reactor, under a nitrogen stream, 1.36 g (2.57 millimoles) of [1,2-bis (diphenylphosphino)ethane]dichloronickel(II) was dissolved in 20 ml of tetrahydrofuran. To this suspension there was added a solution of 10 g (51.30 millimoles) of <strong>[16657-07-1]7-bromoindene</strong> in 100 ml of tetrahydrofuran, prepared based on the method described in J. Org. Chem. 49, 4226-4237(1984). After dropwise addition of 51 ml (102.60 millimoles) of isopropylmagnesium bromide (2N) to the mixed solution while cooling on ice, the mixture was heated to reflux for 20 hours. After reflux, hydrolysis was performed with a saturated aqueous solution of ammonium chloride, distilled water was added, extraction was performed several times with diethyl ether, and then the extract was washed once with saturated saline and dried over anhydrous magnesium sulfate. After drying, the magnesium sulfate was filtered off and the solvent was purified with a silica gel column to obtain 7.14 g of 7-isopropylindene as a yellow oil (88% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; | Stage A: 4-bromo-3H-indene 30 g of 4-bromo-1-indanol is dissolved in 720 ml of toluene, 27 g of paratoluene sulphonic acid is added, then 0.93 g of 4-tertbutylcatechol is added. The mixture is taken to reflux for one hour. After cooling to 20 C., the organic phase is washed with 25 ml of N sodium hydroxide, dried and concentrated to dryness, and the residue is chromatographed on silica, eluding with a hexane-difluoro dichloro ethane mixture (95-5), and 24.6 g of expected product is isolated. Aromatic 1544 cm-1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; | Stage A: 4-bromo-1,2-epoxyindene 250 ml of pH 8 phosphate buffer, 150 ml of methylene chloride, 200 mg of tetrabutylammonium hydrogenosulphate and 10 g of <strong>[16657-07-1]4-bromo-3H-indene</strong> are mixed together. At 0 C. 10 g of metachloroperbenzoic acid is added in several lots, then the temperature of the mixture is allowed to rise to the ambient over 4 hours, 10 g of metachloroperbenzoic acid is added at 0 C. and the temperature is allowed to rise to 20 C. over 2 hours. 3 g of metachloroperbenzoic acid is added and the mixture is left for 16 hours at ambient temperature, then decanted and extracted with methylene chloride; the extracts are washed with water, with a thiosulphate solution and with water, dried and evaporated to dryness. The residue is chromatographed on silica, eluding with a mixture of hexane and isopropyl ether (9-1) with 3% of triethylamine, and 4.11 g of expected product is isolated. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1'-(2-Hydroxy-1,2,3,4-tetrahydronaphth-3-yl)-spiro[4-bromo-1H-indene-1,4'-piperidine] Hydrochloride (15) The reaction of <strong>[16657-07-1]7-bromo-1H-indene</strong> (3.50 g, 17.94 mmol) with LiN[Si(CH3)3 ]2 and bis(2-chloroethyl)-tert-butyl carbamate (Procedure H) yielded a mixture of two products (5.85 g, 90%) in a ratio of 85:15, respectively, as revealed by HPLC (silica gel, 2% acetone-hexanes). Deprotection (see 21a), subsequent neutralization and extraction into EtOAc yielded, after concentration, 2.2 g (46%) of the crude free base. Trituration of this residue with CH2 Cl2 yielded 27 as a white solid which was collected by filtration, washed with CH2Cl2 and dried at 50 C. in vacuo; mp 310-315 C. (sinters); 1 H NMR (DMSOd6)delta1.30 (d, 2, piperidyl alpha-Heq, J=13.5 Hz), 2.38 (dt, 2, piperidyldelta-Hax, J=12.9 Hz, J'=4.8 Hz), 3.21 (dt, 2, piperidyl alpha-Hax, J=13.4 Hz, J'=2.4 Hz), 3.35 (d, 2, piperidyl alpha-Heq, J=11.1 Hz), 6.78 (d, 1, indenyl C2-H, J=6.0 Hz), 7.14 (t, 1, indenyl C6-H, J=8.4 Hz), 7.26 (d, 1, indenyl C2-H, J=6.0 Hz), 7.29 (d, 1, indenyl C5-H, J=6.0 Hz), 7.40 (d, 1, indenyl C7-H, J=8.4 Hz). A soln of 1M Et3 Al in toluene (0.65 mL) was added dropwise at room temperature, under N2, to a stirring suspension of 27 (0.30 g, 1.13 mmol) in CH2 Cl2 (13 mL). Complete dissolution occurred at the end of the addition. The resulting soln was stirred at r.t. for 40 min at which time a soln of 1,4-dihydronaphthalene oxide in CH2 Cl2 (5 mL), prepared from the corresponding bromohydrin (1.35 mmol) as described in Procedure B above, was added dropwise over 5 min. Stirring was contd for 21 h. The reaction was quenched by dropwise addition of 4N NaOH (20 mL). The resulting mixture was stirred vigorously for 2 h, diluted with H2 O (25 mL) and extracted with CH2 Cl2 (3*30 mL). The combined organic extracts were dried over NaSO4 and conc to a tan solid which was purified by radial flow chromatography on silica gel (hexanes,79:acetone,20:Et3 N,1) to yield an off-white solid (0.30 g, 65%); mp 265-267 C.; 1 H NMR (CDCl3)delta1.45 (d, 2, piperidyl beta-Heq, J=12.9 Hz), 2.10-2.28 (m, 2, piperidyl alpha-Hax), 2.65 (t, 1, piperidyl alpha-Hax, J=11.4 Hz), 2.81-3.11 (m, 7, tetrahydronaphthyl C1-H, C4-H & piperidyl), 3.35 (dd, 1, piperidyl a-Heq, J=16.1 Hz, J'=5.7 Hz), 3.93 (m, 1, CHOH), 6.87 (d, 1, indenyl C2-H, J=5.7 Hz), 6.96 (d, 1, indenyl C3-H, J=5.7 Hz), 7.12 (m, 5, aryl), 7.31 (d, 1, indenyl C5-H, J=7.4 Hz), 7.38 (d, 1, indenyl C7-H, J=7.9 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
PREPARATIVE EXAMPLE 34; In a manner similar to that previously described (e.g. Example 1), 4-bromo-1- indanone was converted to 4-bromo-2-indanone (34A) and then further to (+/-)-34F (LCMS m/z 267/269, MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; 3-bromo-1,2-bis(bromomethyl)benzene; In dichloromethane; at 20℃;Cooling with ice;Product distribution / selectivity; | Another alternative conversion of 34A to 34B is described below: To an ice-cooled mixture of the 34A (crude, 22g, 0.113 mol) in DCM (360 mL) was added sodium bicarbonate (28.5g, 0.339 mol) followed by mCPBA (35.4g, 0.16 mol) portionwise. The reaction was slowly warmed to RT and vigorously stirred for 4 h. The mixture was quenched/washed with 10% solution of aq sodium sulfite followed by a final wash with brine. The organic phase was dried over anhydrous sodium sulfate and concentrated to dryness to provide 34G (100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With sulfuric acid; In water;Reflux; | [00163] 4-Bromo-lH-indene (d): Compound c (150 g, 704 mmol, 1 equiv) was suspended in a mixture of concentrated sulfuric acid (250 mL) and water (1.25 L). The mixture was refluxed overnight. The reaction was cooled and extracted with 1.5 L of dichloromethane. The organic layer was washed with saturated sodium bicarbonate (1.5 L), dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified over silica gel (800 g), eluting with heptanes to give compound d (95 g, 69% yield) as a light yellow oil. |
With sulfuric acid; In water;Reflux; | 4-Bromo-1H-indene (4): Compound 3 (150 g, 704 mmol, 1 equiv) was suspended in a mixture of concentrated sulfuric acid (250 mL) and water (1.25 L). The mixture was refluxed overnight. The reaction was cooled and extracted with 1.5 L of dichloromethane. The organic layer was washed with saturated sodium bicarbonate (1.5 L), dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified over silica gel (800 g), eluting with heptanes to give compound 4 (95 g, 69% yield) as a light yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With tris(pentafluorophenyl)borate; In dichloromethane; at 20℃; for 17h;Glovebox; Inert atmosphere; | General procedure: In glove box, a 1.3-mL GLC vial is charged with B(C6F5)3 (5.0 mol%) and a magnetic stir bar. Into a separatevial are weighed the alkene (1.0 equiv) and the cyclohexa-2,5-dien-1-ylsilane (1.3 equiv). Both reagents are dissolvedin CH2Cl2 (1.0M) and the resulting solution is added to the catalyst. The vial is then capped, and the solution is stirredin the glove box. The reaction is monitored by GLC and typically requires 15 to 24 h stirring at room temperature. Themixture is finally diluted with n-pentane (0.3 mL), filtered over a small Celite/SiO2 column (1 cm Celite covered with0.5 cm SiO2, eluting with n-pentane), and all volatiles are removed under reduced pressure. If necessary, the crudetarget compound is purified by either flash column chromatography or Kugelrohr distillation.Prepared according to GP2 from <strong>[16657-07-1]7-bromo-1H-indene</strong> (39.0 mg, 0.20 mmol, 1.0 equiv) and cyclohexa-2,5-dien-1-yltrimethylsilane (39.6 mg, 0.26 mmol, 1.3 equiv). Conversion was complete after 17 h. Purified by Kugelrohr distillation (10 mbar, 150C). Colorless oil, 35 mg, 65% yield. IR (ATR): /cm-1 = 2952, 2894, 2837, 1567, 1447, 1319, 1248, 1162, 1137, 1117, 1057, 987, 914, 831, 763, 689. 1H NMR (500 MHz, C6D6) delta = 7.25 (d, J = 7.9, 1 H), 6.88 (d, J = 7.3, 1 H), 6.74 (t, J = 7.6, 1 H), 3.03 (dd, J = 16.3, 9.1, 1 H), 2.73 (dt, J = 16.1, 9.9, 2H), 2.59 (dd, J = 15.9, 10.7, 1 H), 1.26 (p, J = 9.8, 1 H), -0.11 (s, 9H). 13C NMR (126 MHz, C6D6) delta = 147.1, 145.5, 129.6, 128.3, 123.2, 120.3, 36.6, 36.1, 25.2, -3.1 (3C). GLC-MS (EI) for (C12H17BrSi): m/z 270.0 [M]+, 255.0 [M-CH3]+. HRMS (EI) exact mass for [M]+: calcd m/z 268.02774, found 268.02740. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
7-Bromo-1H-indene (250 mg, 1.28 mmol), 4-hydroxyphenylboronic acid (212 mg, 1.54 mmol), sodium carbonate (270 mg, 2.56 mmol), Pd(PPh3)4 (catalytic amount), 1,4-dioxane (10 mL), and water (3 mL) were added, and stirred at 90 C for 8 hours. The solvent was distilled away under reduced pressure. Ethyl acetate was used as an extraction solvent, and after washing with a 1 N hydrochloric acid aqueous solution and saturated brine, the resultant was dried over magnesium sulfate. The solvent was distilled away under reduced pressure. To half of the resulting residue, methanol (10 mL) and a catalytic amount of 10% palladium-carbon were added, and stirred in a hydrogen atmosphere at room temperature overnight. The insoluble material was filtered off, and the solvent was distilled away under reduced pressure. An operation similar to that in Step 2 of Example 9 was performed on the resulting residue to thus obtain the title compound. Yield: 3.1 mg (0.007 mmol) MS (ESI, m/z) 442 [M+H]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With dichlorobis(triphenylphosphine)palladium[II]; In 1,2-dimethoxyethane; | (1) Synthesis of 4-(3-t-butylphenyl)indene 40.4 g (205 mmol) of tripotassium phosphate, 200 mL of distilled water, 200 mL of DME, 21.9 g (123 mmol) of 3-t-butylphenylboronic acid, 20.0 g (102 mmol) of <strong>[16657-07-1]7-bromo-1H-indene</strong>, 720 mg (1.02 mmol) of dichlorobis(triphenylphosphine)palladium, and 537 mg (2.05 mmol) of triphenyl phosphine were put into a 500-mL glass reactor in that order, and then heated under reflux at 90 C. for 15 hours. This was left cooled to room temperature, transferred into a separatory funnel, and extracted three times with ethyl acetate. The ethyl acetate solution was washed three times with saturated saline water, and dried with sodium sulfate. Sodium sulfate was filtered away, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent, petroleum ether) to give 22.7 g (yield 89%) of 4-(3-t-butylphenyl)indene as a yellow oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With dichlorobis(triphenylphosphine)palladium[II]; In 1,2-dimethoxyethane; | (1) Synthesis of 4-(2,3-dimethylphenyl)indene 38 g (180 mmol) of tripotassium phosphate, 100 mL of distilled water, 100 mL of DME, 10 g (66.7 mmol) of 2,3-dimethylphenylboronic acid, 10.8 g (55.4 mmol) of <strong>[16657-07-1]7-bromo-1H-indene</strong>, 1.0 g (1.42 mmol) of dichlorobis(triphenylphosphine)palladium, and 1.30 g (4.96 mmol) of triphenyl phosphine were put into a 500-mL glass reactor in that order, and then heated under reflux at 90 C. for 11 hours. This was left cooled to room temperature, and the reaction liquid was poured into 100 mL of distilled water, transferred into a separatory funnel, and extracted three times with hexane. 6 mL of concentrated hydrochloric acid was added to the hexane solution at room temperature, then stirred at room temperature for 30 minutes, the palladium compound was precipitated, filtered away through filter paper, and the filtrate was washed three times each with saturated saline water and distilled water, and then dried with sodium sulfate. Sodium sulfate was filtered away, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent, hexane/diisopropyl ether=20/1) to give 11.66 g (yield 96%) of 4-(2,3-dimethylphenyl)indene as a colorless oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With dichlorobis(triphenylphosphine)palladium[II]; In 1,2-dimethoxyethane; | (1) Synthesis of 4-(3-methylphenyl)indene 38 g (180 mmol) of tripotassium phosphate, 100 mL of distilled water, 100 mL of DME, 10 g (73.6 mmol) of 3-methylphenylboronic acid, 12.0 g (61.5 mmol) of <strong>[16657-07-1]7-bromo-1H-indene</strong>, 323 mg (0.460 mmol) of dichlorobis(triphenylphosphine)palladium, and 432 mg (1.65 mmol) of triphenyl phosphine were put into a 500-mL glass reactor in that order, and then heated under reflux at 90 C. for 8 hours. This was left cooled to room temperature, then the reaction liquid was poured into 100 mL of distilled water, transferred into a separatory funnel, and extracted three times with hexane. At room temperature 6 mL of concentrated hydrochloric acid was added to the hexane solution, then stirred at room temperature for 30 minutes, the palladium compound was precipitated, filtered out through filter paper, and the filtrate was washed three times each with saturated saline water and distilled water, and dried with sodium sulfate. Sodium sulfate was filtered away, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent, hexane/diisopropyl ether=20/1) to give 12.7 g (yield 100%) of 4-(3-methylphenyl)indene as a colorless oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With dichlorobis(triphenylphosphine)palladium[II]; In 1,2-dimethoxyethane; | (1) Synthesis of 4-(2-methylphenyl)indene 38 g (180 mmol) of tripotassium phosphate, 100 mL of distilled water, 100 mL of DME, 10 g (73.6 mmol) of 2-methylphenylboronic acid, 12.0 g (61.5 mmol) of <strong>[16657-07-1]7-bromo-1H-indene</strong>, 1.00 g (1.42 mmol) of dichlorobis(triphenylphosphine)palladium, and 1.30 g (4.96 mmol) of triphenyl phosphine were put into a 500-mL glass reactor in that order, and then heated under reflux at 90 C. for 11 hours. This was left cooled to room temperature, then the reaction liquid was poured into 100 mL of distilled water, transferred into a separatory funnel, and extracted three times with hexane. At room temperature 6 mL of concentrated hydrochloric acid was added to the hexane solution, then stirred at room temperature for 30 minutes, the palladium compound was precipitated, filtered out through filter paper, and the filtrate was washed three times each with saturated saline water and distilled water, and dried with sodium sulfate. Sodium sulfate was filtered away, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent, hexane/diisopropyl ether=20/1) to give 12.7 g (yield 100%) of 4-(2-methylphenyl)indene as a colorless oil. |
Tags: 16657-07-1 synthesis path| 16657-07-1 SDS| 16657-07-1 COA| 16657-07-1 purity| 16657-07-1 application| 16657-07-1 NMR| 16657-07-1 COA| 16657-07-1 structure
A284418 [79996-99-9]
1-Bromo-4-(bromomethyl)naphthalene
Similarity: 0.94
A284418 [79996-99-9]
1-Bromo-4-(bromomethyl)naphthalene
Similarity: 0.94
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P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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