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Chemical Structure| 1629869-44-8 Chemical Structure| 1629869-44-8
Chemical Structure| 1629869-44-8

Pimodivir

CAS No.: 1629869-44-8

Pimodivir is an inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC).

4.5 *For Research Use Only !

95%95%
Cat. No.: A304072 Purity: 95%

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Product Details of Pimodivir

CAS No. :1629869-44-8
Formula : C20H19F2N5O2
M.W : 399.39
SMILES Code : O=C([C@H]1C(CC2)CCC2[C@@H]1NC3=NC(C4=CNC5=NC=C(F)C=C54)=NC=C3F)O
MDL No. :MFCD31382121

Safety of Pimodivir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03768609 Healthy Phase 1 Not yet recruiting February 25, 2019 Belgium ... More >> Clinical Pharmacology Unit Not yet recruiting Merksem, Belgium, 2170 Less <<
NCT03376321 Influenza A Phase 3 Recruiting May 1, 2020 -
NCT03381196 Influenza A Phase 3 Recruiting October 29, 2019 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.52mL

2.50mL

1.25mL

25.04mL

5.01mL

2.50mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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