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Chemical Structure| 1628838-42-5 Chemical Structure| 1628838-42-5
Chemical Structure| 1628838-42-5

RAF709

CAS No.: 1628838-42-5

RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 0.5 nM and 1.8 nM, respectively.

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Cat. No.: A684624 Purity: 98%

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Product Details of RAF709

CAS No. :1628838-42-5
Formula : C28H29F3N4O4
M.W : 542.55
SMILES Code : O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC=CC(C(F)(F)F)=C5
MDL No. :MFCD30534393
InChI Key :FYNMINFUAIDIFL-UHFFFAOYSA-N
Pubchem ID :90408826

Safety of RAF709

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of RAF709

MAPK

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
Mouse ovarian granulosa cells 5 nM 6 hours Inhibition of RAF1 activity decreased ERK phosphorylation and suppressed CYP19A1 expression, thereby inhibiting E2 synthesis PMC9011243

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
Mice Wild-type female mice Intraperitoneal injection 30 mg/kg Single dose Inhibition of RAF1 activity reduced serum E2 levels PMC9011243

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.84mL

0.37mL

0.18mL

9.22mL

1.84mL

0.92mL

18.43mL

3.69mL

1.84mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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