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Chemical Structure| 1621526-49-5 Chemical Structure| 1621526-49-5

Structure of 1621526-49-5

Chemical Structure| 1621526-49-5

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Product Details of [ 1621526-49-5 ]

CAS No. :1621526-49-5
Formula : C3H2BrFN2
M.W : 164.96
SMILES Code : FC1=CNN=C1Br
MDL No. :MFCD20926086

Safety of [ 1621526-49-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1621526-49-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1621526-49-5 ]

[ 1621526-49-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1621526-49-5 ]
  • [ 51421-99-9 ]
  • [ 1621525-53-8 ]
YieldReaction ConditionsOperation in experiment
INTERMEDIATE 62 4-("3-Bromo-4-fluoro-lH"-pyrazol-l-vn-2-methoxypyrimidine To a solution of 3-bromo-4-fluoro-lH-pyrazole (500 mg, 3.03 mmol) in anhydrous DMSO (6 mL) was added NaH (133 mg, 3.13 mmol) at 0C. The mixture was stirred for 30 min at 0 C, followed by the addition of <strong>[51421-99-9]4-chloro-2-methoxypyrimidine</strong> (438 mg, 3.03 mmol) in DMSO (2 mL). The resulting mixture was stirred at 90 C overnight. The mixture was cooled to room temperature, quenched with water (10 mL) and extracted with EtOAc (40 mL x 3). The organic layer was collected and dried over Na2S04. The solvent was removed in vacuo to give the crude product. This was purified by flash chromatography (ISCO Combiflash, 24g, Biotage Si column, ~60 mL/min, 100% hexanes 5 min, gradient to 100% EtOAc in hexanes 15 min) to afford 4-(3-bromo-4-fluoro-lH-pyrazol-l-yl)-2-methoxypyrimidine. LCMS calc. = 274.98; found = 274.90 (M+H)+.
 

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