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Chemical Structure| 1621525-50-5 Chemical Structure| 1621525-50-5

Structure of 1621525-50-5

Chemical Structure| 1621525-50-5

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4-(3-Iodo-1H-pyrazol-1-yl)-2-methylpyrimidine

CAS No.: 1621525-50-5

,95%

4.5 *For Research Use Only !

Cat. No.: A1468954 Purity: 95%

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    Product Details of [ 1621525-50-5 ]

    CAS No. :1621525-50-5
    Formula : C8H7IN4
    M.W : 286.07
    SMILES Code : CC1=NC=CC(N2N=C(I)C=C2)=N1

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    Application In Synthesis of [ 1621525-50-5 ]

    * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

    • Downstream synthetic route of [ 1621525-50-5 ]

    [ 1621525-50-5 ] Synthesis Path-Downstream   1~1

    • 1
    • [ 4994-86-9 ]
    • [ 4522-35-4 ]
    • [ 1621525-50-5 ]
    YieldReaction ConditionsOperation in experiment
    INTERMEDIATE 59 4-(3-Iodo-lH-pyrazol-l -yl)-2-methylpyrimidine To a solution of 3-iodo-lH-pyrazole (500 mg, 2.58 mmol) in anhydrous DMSO (6 mL) was added NaH (155 mg, 3.87 mmol) at 0 C. The mixture was stirred for 30 min at 0 C, followed by the addition of 4-chloro-2-methylpyrimidine (331 mg, 2.58 mmol) in DMSO (2 mL). The resulting mixture was stirred at 90 C overnight. The mixture was cooled to room temperature, quenched with water (10 mL) and extracted EtOAc (40 mL x 3). The organic layer was collected and dried over Na2S04. The solvent was removed in vacuo to give the crude product. This was purified by flash chromatography (ISCO Combiflash, 24 g, Biotage Si column, -60 mL/min, 100% hexanes 5 min, gradient to 100% EtOAc in hexanes 15 min) to afford 4-(3-iodo-17J- pyrazol-l-yl)-2-methylpyrimidine. LCMS calc. = 286.98; found = 286.95 (M+H)+.
     

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