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Chemical Structure| 16172-23-9 Chemical Structure| 16172-23-9

Structure of 16172-23-9

Chemical Structure| 16172-23-9

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Product Details of [ 16172-23-9 ]

CAS No. :16172-23-9
Formula : C9H7NOS
M.W : 177.22
SMILES Code : SC1=NC=C(C2=CC=CC=C2)O1
MDL No. :MFCD08704427

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Application In Synthesis of [ 16172-23-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 16172-23-9 ]
  • Downstream synthetic route of [ 16172-23-9 ]

[ 16172-23-9 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 16172-23-9 ]
  • [ 62124-43-0 ]
YieldReaction ConditionsOperation in experiment
18% at 0 - 120℃; for 3 h; Step a:
Preparation of 2-chloro-5-phenyloxazole
0.29 g (2.8 mmol) of triethylamine is added to a mixture of 0.5 g (2.8 mmol) of 5-phenyl-3H-oxazole-2-thione (FR 1,450,443) and 2.3 mL of phosphoryl chloride cooled to 0° C.
The mixture is heated to 120° C. for 3 hours.
The medium is diluted with ethyl acetate and washed with water.
The organic phase is dried over magnesium sulfate, filtered and concentrated.
The product is purified by silica gel chromatography (eluent: 15/85 ethyl acetate/heptane).
Chestnut brown viscous oil; Yield: 18percent 1H NMR (CDCl3): 7.7 to 7.55 (unresolved peaks, 2H); 7.5 to 7.3 (unresolved peaks, 3H); 7.25 (singlet, 1H)
References: [1] Patent: US2006/89364, 2006, A1, . Location in patent: Page/Page column 28-29.
  • 2
  • [ 16172-23-9 ]
  • [ 62124-43-0 ]
References: [1] Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1610 - 1619.
 

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