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Chemical Structure| 1613228-52-6 Chemical Structure| 1613228-52-6

Structure of 1613228-52-6

Chemical Structure| 1613228-52-6

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Product Details of [ 1613228-52-6 ]

CAS No. :1613228-52-6
Formula : C23H26N6O3
M.W : 434.49
SMILES Code : O=C(NC1=CC=CC(NC2=NC=C(NC(C3=CC(N)=CC=C3C)=O)C=N2)=C1)OC(C)(C)C

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Application In Synthesis of [ 1613228-52-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1613228-52-6 ]

[ 1613228-52-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1613228-52-6 ]
  • [ 147404-69-1 ]
  • C37H36N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; General procedure: Step1: 29a (0.10 g, 0.23 mmol), isoquinoline-6-carboxylic acid(0.044 g, 0.25 mmol) and HATU (0.174 g, 0.46 mmol) were dissolvedin 2 mL DMF, followed by the addition of DIEA (0.08 mL,0.46 mmol). The reaction was kept stirring at room temperatureovernight. The resulting mixture was partitioned between ethylacetate and saturated aqueous sodium bicarbonate. The organicswere washed with brine, dried over magnesium sulfate, concentratedand purified by column chromatography to yield yellowsolids (0.087 g, 64%).Step2The yellow solids (0.087 g, 0.14 mmol) produced in the laststep were suspended in2mLTFA and2mL DCM. The reaction wasstirred at room temperature for 2 h and concentrated in vacuum.The obtained solid was washed with diethyl ether, then gained thetitle compound 20 as a brown solid (0.030 g, 44%).
 

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