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Chemical Structure| 160969-02-8 Chemical Structure| 160969-02-8

Structure of 160969-02-8

Chemical Structure| 160969-02-8

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Product Details of [ 160969-02-8 ]

CAS No. :160969-02-8
Formula : C10H11F3O3
M.W : 236.19
SMILES Code : FC(F)(F)COC1=CC=CC=C1OCCO
MDL No. :MFCD25959685

Safety of [ 160969-02-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 160969-02-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 160969-02-8 ]

[ 160969-02-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 124-63-0 ]
  • [ 160969-02-8 ]
  • [ 160969-03-9 ]
YieldReaction ConditionsOperation in experiment
92.5% With triethylamine In dichloromethane at 0 - 20℃; for 4 h; Reflux In a 5000 mL four-necked flask equipped with mechanical stirring, 200 g (0.85 mol, 1.0 eq) of 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl alcohol which was involved in the reaction was sequentially added. ,The temperature of the reaction system was lowered to about 0 ° C under 155 g (1.53 mol, 1.8 eq) of triethylamine and 2400 ml of ice cream in dichloromethane.388 g (3.4 mol, 4.0 eq) of methanesulfonyl chloride dissolved in 1000 ml of dichloromethane was slowly added dropwise.The temperature of the reaction system was controlled to be not higher than 20 °C. After the addition is completed, remove the ice salt bath.The temperature was raised to reflux for 4 hours, cooled to room temperature, and triethylamine hydrochloride was removed by filtration.The filtrate was washed with 1000 ml of *3 saturated sodium carbonate.Dry over anhydrous sodium sulfate, filter, dry EtOAc m.400 g of isopropanol was added and stirred at 0 ° C for 6 hours, and filtered.Vacuum drying to 247 g of a white solid.Melting point 39-42 ° C,The yield is 92.5percent.The purity is 98.3percent.
References: [1] Patent: CN109516933, 2019, A, . Location in patent: Paragraph 0043; 0051-0053; 0061-0063 0071-0073; 0081-0082.
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 17, p. 2674 - 2687.
[3] Patent: US5387603, 1995, A, .
[4] Patent: WO2011/101864, 2011, A1, . Location in patent: Page/Page column 23.
 

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