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Chemical Structure| 160539-04-8

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Product Details of [ 160539-04-8 ]

CAS No. :160539-04-8
Formula : C10H9N3
M.W : 171.20
SMILES Code : NC1=CN=C(C2=NC=CC=C2)C=C1
MDL No. :MFCD12033465
InChI Key :LRBYBVNTZSPBNA-UHFFFAOYSA-N
Pubchem ID :9877498

Safety of [ 160539-04-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 160539-04-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 160539-04-8 ]

[ 160539-04-8 ] Synthesis Path-Downstream   1~35

  • 3
  • 5-(ethoxycarbonylamido)-2,2'-bipyridine [ No CAS ]
  • [ 160539-04-8 ]
  • 4
  • [ 140-89-6 ]
  • [ 160539-04-8 ]
  • [ 187461-65-0 ]
  • 5
  • [ 67-56-1 ]
  • [ 57120-17-9 ]
  • [ 160539-04-8 ]
  • 21-([2,2']bipyridinyl-5-ylcarbamoyl)-heneicosa-10,12-diynoic acid methyl ester [ No CAS ]
  • bis[N-5'-(2',2''-bipyridyl)]-10,12-docosadiyne-1,22-diamide [ No CAS ]
  • 6
  • [ 66990-30-5 ]
  • [ 160539-04-8 ]
  • [N5'-(2',2''-bipyridyl)]-10,12-tricosadiyne-1-amide [ No CAS ]
  • 7
  • [ 160539-04-8 ]
  • 5,7-dodecadiyne-1,12-dicarbonyl chloride [ No CAS ]
  • bis[N-5'-(2',2''-bipyridyl)]-5,7-dodecadiyne-1,12-diamide [ No CAS ]
  • 8
  • [ 478548-86-6 ]
  • [ 160539-04-8 ]
YieldReaction ConditionsOperation in experiment
37.8% With hydroxylamine hydrochloride; triethylamine; In ethanol; water; at 80℃; for 20h; Method A: The mixture of 66 5-(2,5-dimethyl-1H-pyrrol-1-yl)-2,2'-bipyridine (75.6 mg, 0.3 mmol), 72 hydroxylamine hydrochloride (210.7 mg, 3.0 mmol) and 73 triethylamine (0.084 mL, 0.6 mmol) in 1.4 mL 74 ethanol and 0.6 mL of 75 H2O was stirred at 80C for 20 hours. The mixture was poured over 76 HCl 1M and was washed with diethyl ether. The aqueous layer was neutralized and basified with NaOH 5M and NaOH 2M until obtained pH=9-10 and was extracted with dichloromethane (x3). The different organic layers were collected and were dried. The crude was purified by CombiFlash chromatography column (dichloromethane/dichloromethane:methanol 20%) to afforded the amine derivative (19.6 mg, 37.8%).
  • 9
  • [ 774578-71-1 ]
  • [ 160539-04-8 ]
  • 4,5-bis(thiomethyl)-4'-meta-2,2'-bipyridylcarbamoyltetrathiafulvalene [ No CAS ]
  • 10
  • [ 160539-04-8 ]
  • [ 251901-42-5 ]
  • 4,5-ethylenedithio-4'-meta-2,2'-bipyridylcarbamoyltetrathiafulvalene [ No CAS ]
  • 11
  • [ 585-47-7 ]
  • [ 160539-04-8 ]
  • (aminomethyl)polystyrene [ No CAS ]
  • (2,2-dipyridine-5-yl)-NH-(benzene-1,3-disulfonyl) terminated (aminomethyl)polystyrene [ No CAS ]
  • 12
  • [ 585-47-7 ]
  • [ 160539-04-8 ]
  • O-(2-aminoethyl)polyethylene glycol polystyrene-bond [ No CAS ]
  • (2,2-dipyridine-5-yl)-NH-(benzene-1,3-disulfonyl) terminated O-(2-aminoethyl)polyethylene glycol polystyrene-bond [ No CAS ]
  • 13
  • [ 109-04-6 ]
  • sodium diphenylamide [ No CAS ]
  • [ 160539-04-8 ]
  • 14
  • [ 5350-93-6 ]
  • [ 160539-04-8 ]
  • 15
  • [ 478548-84-4 ]
  • [ 160539-04-8 ]
  • 16
  • [ 4548-45-2 ]
  • potassium-salt of/the/ 4-acetylamino-benzenesulfinic acid [ No CAS ]
  • [ 160539-04-8 ]
  • 17
  • [ 13737-05-8 ]
  • [ 160539-04-8 ]
  • 18
  • [ 160539-04-8 ]
  • [ 187461-66-1 ]
  • 19
  • [ 1025079-80-4 ]
  • [ 160539-04-8 ]
  • [ 1025079-78-0 ]
  • 20
  • [ 13534-97-9 ]
  • [ 882521-96-2 ]
  • [ 120-07-0 ]
  • [ 160539-04-8 ]
  • 21
  • [ 1246767-60-1 ]
  • [ 160539-04-8 ]
  • 22
  • [ 1246767-61-2 ]
  • [ 160539-04-8 ]
  • 23
  • ammonium hexafluorophosphate [ No CAS ]
  • [(HOOC-(2,2′:6′,2″-terpyridine))Ru((2,2′:6′,2″-terpyridine)-NH2)](PF6)2 [ No CAS ]
  • [ 160539-04-8 ]
  • C41H30N10ORu(2+)*2F6P(1-) [ No CAS ]
  • 24
  • [ 2033-24-1 ]
  • [ 122-51-0 ]
  • [ 160539-04-8 ]
  • [ 1414936-65-4 ]
  • 25
  • [ 2033-24-1 ]
  • [ 160539-04-8 ]
  • [ 1414936-66-5 ]
YieldReaction ConditionsOperation in experiment
92% In diethyl ether; at 100℃; for 4h;Inert atmosphere; Reflux; A mixture of 2 g (11.7 mmol) of 5-amino-2,2'-dipyridyl, 2.52 g (17.5 mmol, 1.5 gq) of ISOPROPYLIDENE MALONATE, 8.65 g (58.4 mmol,TriethoxymethaneofMixed, and under argon gas protectionUp to 100 Upon heating, a white slurry-like substance appears immediately. After 5 minutes, stop heating, cool and add 50 ml of methanol. The white solid powder is filtered and washed several times with methanol. Drying yielded an intermediate product, pre-pyND, with a yield of 92%. The method of synthesizing pyND from the intermediate is the same as 8mCND, and the yield is 84%.
  • 26
  • [ 89776-71-6 ]
  • [ 160539-04-8 ]
  • methyl 3-([2,2'-bipyridin]-5-ylamino)-2-cyanobut-2-enoate [ No CAS ]
  • 27
  • [ 89776-71-6 ]
  • [ 160539-04-8 ]
  • 4-hydroxy-2-methyl-6-(pyridin-2-yl)-1,5-naphthyridine-3-carbonitrile [ No CAS ]
  • 28
  • [ 13534-97-9 ]
  • [ 160539-04-8 ]
  • 29
  • [ 13534-97-9 ]
  • [ 17997-47-6 ]
  • [ 160539-04-8 ]
YieldReaction ConditionsOperation in experiment
43.5% With tetrakis(triphenylphosphine) palladium(0); In toluene; at 130℃; for 48h;Inert atmosphere; Method B: To a solution of 55 6-bromopyridin-3-amine (50 mg, 0.29 mmol) in 1.5 mL of dry 63 toluene at room temperature, was added 64 2-(tributylstannyl)pyridine (0.013 mL, 0.35 mmol) dropwise under N2 atmosphere following by the addition of 65 tetrakis(triphenylphosphine)palladium (40.2 mg, 0.03 mmol). The reaction mixture was degassed with nitrogen and was stirred at 130c for two days. The reaction was cooled to room temperature. Next, the mixture was taken up with NaOH 2M and separated with ethyl acetate (x2). The organic layer was washed with brine, was dried with Na2SO4 and the solvent was removed under vacuum. The crude was purified by CombiFlash chromatography column (DCM/DCM:MeOH 20%) to afforded the desired compound (21.6 mg, 43.5 %). 1H-NMR (400 MHz, DMSO-d6): δ = 8.54 (d, 1 H), 8.17 (d, 1 H), 8.08 (d, 1 H), 8.01 (d, 1 H), 7.80 (td, 1 H), 7.25 (m, 1 H), 7.01 (dd, 1 H), 5.65 (s, 2H). HPLC-MS: Rt 2.746; m/z 172.0 (MH+).
  • 30
  • [ 15761-39-4 ]
  • [ 160539-04-8 ]
  • tert-butyl (S)-2-([2,2’-bipyridin]-5-ylcarbamoyl)pyrrolidine-1-carboxylate [ No CAS ]
  • 31
  • [ 23165-29-9 ]
  • [ 160539-04-8 ]
  • 1-([2,2’-bipyridin]-5-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea [ No CAS ]
  • 32
  • [ 4548-45-2 ]
  • [ 160539-04-8 ]
  • 33
  • [ 17997-47-6 ]
  • [ 160539-04-8 ]
  • 34
  • cis-dichloro(2,2′-bipyridine)ruthenium(II)chloride [ No CAS ]
  • ammonium hexafluorophosphate [ No CAS ]
  • [ 160539-04-8 ]
  • C30H25N7Ru(2+)*2F6P(1-) [ No CAS ]
  • 35
  • [ 1656-44-6 ]
  • [ 160539-04-8 ]
  • C16H11N5O6S [ No CAS ]
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 160539-04-8 ]

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Related Parent Nucleus of
[ 160539-04-8 ]

Pyridines

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