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Chemical Structure| 160233-42-1 Chemical Structure| 160233-42-1

Structure of 160233-42-1

Chemical Structure| 160233-42-1

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Product Details of [ 160233-42-1 ]

CAS No. :160233-42-1
Formula : C23H21NO2
M.W : 343.42
SMILES Code : O=C([C@@H]1N(C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C1)OC
MDL No. :MFCD09878842
InChI Key :QGSITPKXYQEFIR-CILPGNKCSA-N
Pubchem ID :10925956

Safety of [ 160233-42-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 160233-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 160233-42-1 ]
  • Downstream synthetic route of [ 160233-42-1 ]

[ 160233-42-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 160233-42-1 ]
  • [ 1239355-46-4 ]
YieldReaction ConditionsOperation in experiment
70% With triethylamine; trifluoroacetic acid In dichloromethane at -10 - 0℃; A mixture of N- trityl -. (R) -2- carboxylate cyclopropylamine (1400g, 4.08mol, 1eq) was added to methylene chloride cooled to 7LAfter -5 slowly added trifluoroacetic acid (700g, 6.14mol, 1.5eq), the reaction mixture was stirred, cooled to -10 was slowly added triethylamine(1600g, 15.84mol, 3.88eq), adjust the pH = 8 or so, slowly dropped BOC anhydride (900g, 4.13mol, 1.01eq),Full temperature -10 ~ 0 , pH = 8. Gussets completion of the reaction, water was added and quenched, washed with hydrochloric acid, the organic phase was dried over anhydrous sulfateSodium sulfate, and spin-dry the organic phase to give a colorless oil, the product is 1-t-butoxycarbonyl (R) -2- hydroxymethyl-cyclopropylamine. Yield70percent.
References: [1] Patent: CN105237560, 2016, A, . Location in patent: Paragraph 0072; 0073.
 

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